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| Names | |
|---|---|
| IUPAC name 9-amino-1,2,3,4-tetrahydroacridin-1-ol | |
| Identifiers | |
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3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| UNII | |
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| Properties | |
| C13H14N2O | |
| Molar mass | 214.268 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Velnacrine, also known as1-hydroxytacrine,[1] is an inhibitor ofcholinesterase enzymes. It is also ametabolite oftacrine.[2]
Velnacrine is able to inhibitacetylcholinesterase (AChE),[3] this results in elevated levels ofacetylcholine, as AChE is the enzyme that hydrolyzes acetylcholine.[4] It is also able to inhibitbutyrylcholinesterase.[5]
Velnacrine, as many othercholinergics, has been described as possibly useful to help manage symptoms of Alzheimer's disease. Some research has described the drug as having benefits over placebo[6] and an acceptable safety profile.[7] However, a review described available data as not proving efficacy and showing evidence of toxicity.[8] Additionally, theFDA voted against recommending approval of velnacrine.[8]
