 | |
| Clinical data | |
|---|---|
| ATC code | |
| Identifiers | |
| |
| CAS Number | |
| PubChemCID | |
| IUPHAR/BPS | |
| DrugBank |
|
| ChemSpider |
|
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.206.770 |
| Chemical and physical data | |
| Formula | C13H16N4O |
| Molar mass | 244.298 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
 N Y (what is this?) (verify) | |
Veliparib (ABT-888)[1] is a potential anti-cancer drug acting as aPARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. Veliparib may make whole brain radiation treatment work more effectively against brain metastases from NSCLC. It has been shown to potentiate the effects of many chemotherapeutics, and as such has been part of many combination clinical trials.[2]
It inhibits bothPARP1 andPARP2[1] and thereby induces synthetic lethality. It is still being evaluated for the treatment ofovarian cancer.[3]
Veliparib is being developed byAbbVie. It was derived from a prior lead compound (A 620223). The FDA awardedorphan drug status in November 2016 for NSCLC.[2]
As of 2017, 96 clinical trials involving veliparib had been registered with the FDA.[4] It was included in theI-SPY2breast cancer trial.[5]
Numerous phase Iclinical trials are in progress.[4]Over 40 phase II clinical trials have been registered, for indications such as metastatic melanoma,[6] NSCLC, prostate cancer[7] and brain tumors associated with metastatic primary tumors.
Combination trials have evaluated veliparib in combination withdoxorubicin,temozolomide,topotecan,carboplatin,paclitaxel,pemetrexed,cyclophosphamide,gemcitabine, and others.[4]
By June 2014 it was in three phase III trials, for advanced ovarian cancer,triple-negative breast cancer and innon-small cell lung cancer (NSCLC).[8] In 2017, AbbVie reported that veliparib failed to improve outcomes in the triple-negative breast cancer and NSCLC trials.[9]