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Valperinol

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Valperinol
Clinical data
ATC code
  • None
Legal status
Legal status
  • In general: non-regulated
Identifiers
  • (1R,3R,4S,6R,7S,8R,10R)-8-methoxy-10-methyl-3-(1-piperidinylmethyl)-2,9-dioxatricyclo[4.3.1.03,7]decan-4-ol
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H27NO4
Molar mass297.395 g·mol−1
3D model (JSmol)
  • O1[C@@H](OC)[C@@H]2[C@@]3(O[C@H]1[C@@H]([C@H]2C[C@@H]3O)C)CN4CCCCC4
  • InChI=1S/C16H27NO4/c1-10-11-8-12(18)16(9-17-6-4-3-5-7-17)13(11)15(19-2)20-14(10)21-16/h10-15,18H,3-9H2,1-2H3/t10-,11-,12+,13-,14+,15-,16-/m1/s1
  • Key:KZSHXABWNBVUTK-GBIHRFPISA-N

Valperinol (INN;GA 30-905) is adrug which acts as acalcium channel blocker.[1][2] It was patented as a possiblesedative,antiepileptic, and/orantiparkinsonian agent, but was never marketed.[3]

References

[edit]
  1. ^Thies PW, Asai A, Bán I, David S, Finner E (1984). "[The synthesis of valperinol and various 3-aminomethyl derivatives of 2,9-dioxatricyclo[4,3,1,0(3,7)]decane from didrovaltrate]".Arzneimittel-Forschung (in German).34 (11):1460–3.PMID 6543120.
  2. ^Dose M (1984). "[Calcium antagonist properties of valperinol]".Arzneimittel-Forschung (in German).34 (11):1464–6.PMID 6098282.
  3. ^Dictionary of Pharmacological Agents Volume 2. CRC Press. 1996-11-21. p. 2104.ISBN 978-0-412-46630-4. Retrieved22 April 2012.
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
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