 | |
| Names | |
|---|---|
| IUPAC name L-Valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutamine | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
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| |
| Properties | |
| C44H61N9O11 | |
| Molar mass | 892.024 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Valorphin, also known asVV-hemorphin-5, is anaturally occurring,endogenousopioidheptapeptide of thehemorphin family with theamino acid sequence H-Val-Val-Tyr-Pro-Trp-Thr-Gln-OH (VVYPWTQ).[1][2][3] It is produced in the body viaproteolyiccleavage ofresidues 33-39 of the β-chain ofhemoglobin.[2][4] Valorphin binds preferentially to theμ-opioid receptor and produces effects such asanalgesia andself-administration in animals.[1][2] It also possessescytotoxic andantiproliferative properties againsttumorcells,[3][4][5][6] the mediation of which, because they are reversed bynaloxone, appears to be dependent on theopioid receptors.[5]
