 | |
| Names | |
|---|---|
| IUPAC name 3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.209.922 |
| EC Number |
|
| |
| |
| Properties | |
| C18H19N3O2S | |
| Molar mass | 341.43 g·mol−1 |
| Hazards | |
| GHS labelling:[1] | |
 | |
| Danger | |
| H301,H319 | |
| P264,P264+P265,P270,P280,P301+P316,P305+P351+P338,P321,P330,P337+P317,P405,P501 | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
VU-0152100 is a positive modulator of theM4 receptor,[1] one of themuscarinic acetylcholine receptors.
In mice, VU-0152100 is able to decrease self-administration of cocaine, this is thought to come from the M4 receptor's action onD1 containing dopaminergic neurons.[2] It is also able to almost completely inhibit thehyperactivity caused by cocaine.[3] Another study has shown that this drug is able to reverse hyperlocomotion induced by amphetamine, in an anti-psychotic-like manner.[4] This data suggests that it could potentially be developed as a treatment for stimulant abuse.
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