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VTI1B

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

VTI1B

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2V8S

Identifiers

Aliases

VTI1B, VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1, vesicle transport through interaction with t-SNAREs 1B

External IDs

OMIM:603207;MGI:1855688;HomoloGene:38178;GeneCards:VTI1B;OMA:VTI1B - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q24.1	Start	67,647,085bp^[1]
Band	14q24.1	End	67,674,820bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 C3	Start	79,202,791bp^[2]
Band	12\|12 C3	End	79,219,441bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

C1 segment

Amygdala

anterior cingulate cortex

nucleus accumbens

prefrontal cortex

right frontal lobe

putamen

caudate nucleus

Hypothalamus

optic nerve

Top expressed in

dorsal striatum

globus pallidus

olfactory tubercle

Amygdala

nucleus accumbens

transitional epithelium of urinary bladder

cingulate gyrus

arcuate nucleus

prefrontal cortex

paraventricular nucleus of hypothalamus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	SNAP receptor activity protein binding chloride channel inhibitor activity SNARE binding
Cellular component	integral component of membrane recycling endosome vesicle endosome Golgi apparatus intracellular membrane-bounded organelle late endosome membrane synaptic vesicle membrane lysosomal membrane soma perinuclear region of cytoplasm lysosome ER to Golgi transport vesicle membrane SNARE complex endoplasmic reticulum membrane extracellular region cytosol platelet alpha granule lumen early endosome membrane recycling endosome membrane
Biological process	membrane fusion vesicle docking involved in exocytosis autophagosome maturation protein transport cell population proliferation intracellular protein transport vesicle-mediated transport regulation of protein localization to plasma membrane Golgi to vacuole transport vesicle fusion with Golgi apparatus endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport protein targeting to vacuole retrograde transport, endosome to Golgi platelet degranulation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


10490


53612

Ensembl


ENSG00000100568


ENSMUSG00000021124

UniProt


Q9UEU0


O88384

RefSeq (mRNA)


NM_006370


NM_016800 NM_001364374

RefSeq (protein)


NP_006361


n/a

Location (UCSC)

Chr 14: 67.65 – 67.67 Mb

Chr 12: 79.2 – 79.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Vesicle transport through interaction with t-SNAREs homolog 1B is aprotein that in humans is encoded by theVTI1Bgene.^[5]^[6]^[7]

Interactions

[edit]

VTI1B has been shown tointeract withSTX8.^[8]^[9]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000100568 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000021124 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Li HC, Tahara H, Tsuyama N, Ide T (July 1998). "A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts".Biochem Biophys Res Commun.247 (1):70–4.doi:10.1006/bbrc.1998.8737.PMID 9636656.
^Fischer von Mollard G, Stevens TH (February 1998)."A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways".J Biol Chem.273 (5):2624–30.doi:10.1074/jbc.273.5.2624.PMID 9446565.
^"Entrez Gene: VTI1B vesicle transport through interaction with t-SNAREs homolog 1B (yeast)".
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
^Subramaniam VN, Loh E, Horstmann H, Habermann A, Xu Y, Coe J, Griffiths G, Hong W (March 2000)."Preferential association of syntaxin 8 with the early endosome"(PDF).J. Cell Sci.113 (6):997–1008.doi:10.1242/jcs.113.6.997.PMID 10683148.