Urine protein/creatinine ratio is a widely usedinitial method to estimate dailyprotein excretion in urine.[1][2][3] Since the diagnosis and management ofproteinuric diseases, many of which affect the renal system, and the staging ofchronic kidney disease depend on accurate identification and quantitation of proteinuria,[4][1] the implementation of the 24-hour urine collection is the most accurate procedure in practice to figure out the urinary protein excretion.[1] However, in current clinical practice, the urine protein/creatinine ratio is widely used toestimate daily protein excretion by virtue of its convenience and simplicity.[5][1]
The difference between urine protein/creatinine ratio and 24-hour urine collection is that the former requires a urine sample to be collected only once at any time.[6] [Creatinine(U)] is taken into account due to the notion thatcreatinine is normally released into the urine at a constant rate.[6] Scientists found that the ratio of protein to creatinine roughly estimates the actual value gained from the 24-hour urine protein test.[6] The normal urine protein/creatinine ratio is less than 200 mg/g.[7]
^National Kidney Foundation (2002), "K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification",American Journal of Kidney Diseases,39 (2 Suppl 1): S1–266,ISSN0272-6386,PMID11904577
^Ginsberg, Jay M.; Chang, Bruce S.; Matarese, Richard A.; Garella, Serafino (1983-12-22). "Use of Single Voided Urine Samples to Estimate Quantitative Proteinuria".The New England Journal of Medicine.309 (25). Massachusetts Medical Society:1543–1546.doi:10.1056/nejm198312223092503.ISSN0028-4793.PMID6656849.
