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Testing of umifenovir's efficacy has mainly occurred in China and Russia,[7][8] and it is well known in these two countries.[9] Some of the Russian tests showed the drug to be effective againstinfluenza A and a direct comparison withoseltamivir showed similar efficiencyin vitro and in a clinical setting.[7][10] In 2010 Arbidol was the drug brand with the highest sales volume in Russia.[11] In the first quarter of 2020 it had a 16 percent share in the Russian antiviral market.[12]
Some preliminary research suggests it could be useful forflavivirus infection like West Nile virus.[14]
Some studies also indicate that umifenovir also hasin vitro effectiveness at preventing entry ofZaire ebolavirus (Kikwit strain), Tacaribearenavirus andKaposi's sarcoma-associated herpesvirus in mammalian cell cultures, while confirming umifenovir's suppressive effectin vitro onHepatitis B andpoliovirus infection of mammalian cells when introduced either in advance of viral infection or during infection.[15][16]
Umifenovir inhibits membrane fusion of influenza virus in vitro.[18] Fusion between the viral envelope (surrounding theviral capsid) and thecell membrane of the target cell is inhibited.[19][20] This prevents viral entry to the target cell, and therefore protects it from infection.[21]
Some evidence suggests that the drug's actions are more effective at preventing infections fromRNA viruses than infections fromDNA viruses.[22]
The maximum concentration of umifenovir in blood plasma when taking a dose of 50 mg is achieved after 1.2 hours, with 100 mg the maximum dose is obtained after 1.5 hours.[3] The bioavailability of the drug is about 40% and does not depend on food intake.[3]
The half-life is about 17-21 hours.[3][4] It is metabolized in the liver primarily byCYP3A4 but also by several other enzymes.[4] About 40% is excreted unchanged, mainly in bile (38.9%) and in small amounts by the kidneys (0.12%). During the first 24 hours, 90% of the administered dose is eliminated.[4]
Chemically, umifenovir features anindole core, functionalized at all but one positions with different substituents. The molecular groups of umifenovir - hydroxy, amino and carboxy - can form different hydrogen-bondedsynthons.[citation needed] Umifenovir is characterized by only one polymorphic form but can exist in the form of a large number of crystal solvates, the production of which depends on the medium and conditions of synthesis. Umifenovir is poorly soluble in water. Crystalline solvates and other solid forms may be determined by the spatial structure and conformational equilibria in the saturated solution.[24][25]
In 2006 the American company Good Earth Medicine applied to the FDA for anEmergency Use Authorization of Arbidol during theH5N1 bird flu epidemic, but their application was rejected on the grounds that the lab data provided was not strong enough to justify use.[26][27]
In 2007, the Russian Academy of Medical Sciences stated that the effects of Arbidol (umifenovir) are not scientifically proven.[28]
In the early 2010s Russian media criticized lobbying attempts byTatyana Golikova (then-Minister of Healthcare) to promote umifenovir,[29] and the unsubstantiated claim that Arbidol can speed up recovery from flu or cold by 1.3-2.3 days.[30] They also made claims that comparative clinical studies have proven umifenovir to be inefficient.[31][32]
In January 2020, the Russian drug company OTCPharm (Отисифарм) published advertisements stating that the drug is effective againstSARS-CoV-2. Shortly afterwards the RussianFederal Antimonopoly Service fined the company for violation of its advertising rules.[33] In March 2020 a video promoting the drug forCOVID-19 went viral on Facebook and circulated heavily on WhatsApp, and around the same time a shortage of the drug ensued in Russia.[34]
In early 2020 umifenovir was touted as a potential treatment forCOVID-19 in China, where it was sometimes given to patients in combination with other drugs such as the anti-HIV drugDarunavir.[35][36][37][38][39] A three-arm RCT study published in May 2020 in theCell Press journalClinical Advances found that neither Umifenovir orLopinavir/Ritonavir helped patients with mild to moderate COVID-19.[40] A similar study comparing Umifenovir directly with Lopinavir/Ritonavir found no difference in fever duration between the two groups but found a lower viral load on day 14 in the Umifenovir group.[41] A systemic review and meta-analysis of 16 studies on Umifenovir published in March 2021 concluded that there is "no significant benefit of using Arbidol compared with non‐antiviral treatment or other therapeutic agents against COVID‐19 disease."[42]
^Wang MZ, Cai BQ, Li LY, Lin JT, Su N, Yu HX, et al. (June 2004). "[Efficacy and safety of arbidol in treatment of naturally acquired influenza]".Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae.26 (3):289–293.PMID15266832.
^Boriskin YS, Leneva IA, Pécheur EI, Polyak SJ (2008). "Arbidol: a broad-spectrum antiviral compound that blocks viral fusion".Current Medicinal Chemistry.15 (10):997–1005.doi:10.2174/092986708784049658.PMID18393857.
^Leneva IA, Russell RJ, Boriskin YS, Hay AJ (February 2009). "Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol".Antiviral Research.81 (2):132–140.doi:10.1016/j.antiviral.2008.10.009.PMID19028526.
^Shi L, Xiong H, He J, Deng H, Li Q, Zhong Q, et al. (2007). "Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo".Archives of Virology.152 (8):1447–1455.doi:10.1007/s00705-007-0974-5.PMID17497238.S2CID13595688.
^Glushkov RG, Gus'kova TA, Krylova LI, Nikolaeva IS (1999). "[Mechanisms of arbidole's immunomodulating action]".Vestnik Rossiiskoi Akademii Meditsinskikh Nauk (in Russian) (3):36–40.PMID10222830.
^Belov KV, Dyshin AA, Khodov IA (March 2024). "Conformational analysis of arbidol in supercritical carbon Dioxide: Insights into 'opened' and 'closed' conformer groups".Journal of Molecular Liquids.397 124074.doi:10.1016/j.molliq.2024.124074.S2CID267232952.
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