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Ulp1 peptidase

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Class of enzymes

Ulp1 peptidase

Identifiers

Databases

PDB structures

Ulp1 peptidase (EC 3.4.22.68,Smt3-protein conjugate proteinase,Ubl-specific protease 1,Ulp1,Ulp1 endopeptidase,Ulp1 protease) is anenzyme.^[1]^[2]^[3]^[4]^[5]^[6] This enzymecatalyses the followingchemical reaction

Hydrolysis of the alpha-linkedpeptide bond in the sequence Gly-Gly-!Ala-Thr-Tyr at theC-terminal end of the smallubiquitin-like modifier (SUMO) propeptide, Smt3

The enzyme fromSaccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human.

^Lima CD, Rawlings ND, Woessner JF (2004). "Ulp1 endopeptidase". In Barrett AJ (ed.).Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. pp. 1340–1344.
^Li SJ, Hochstrasser M (March 1999). "A new protease required for cell-cycle progression in yeast".Nature.398 (6724):246–51.doi:10.1038/18457.PMID 10094048.
^Taylor DL, Ho JC, Oliver A, Watts FZ (March 2002). "Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease".Journal of Cell Science.115 (Pt 6):1113–22.PMID 11884512.
^Li SJ, Hochstrasser M (March 2003)."The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity".The Journal of Cell Biology.160 (7):1069–81.doi:10.1083/jcb.200212052.PMC 2172760.PMID 12654900.
^Ihara M, Koyama H, Uchimura Y, Saitoh H, Kikuchi A (June 2007)."Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth".The Journal of Biological Chemistry.282 (22):16465–75.doi:10.1074/jbc.M610723200.PMID 17428805.
^Mukhopadhyay D, Dasso M (June 2007). "Modification in reverse: the SUMO proteases".Trends in Biochemical Sciences.32 (6):286–95.doi:10.1016/j.tibs.2007.05.002.PMID 17499995.

Ulp1+peptidase at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

v t e Proteases:cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain 3C-like protease Gingipain R Gingipain K

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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