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Udenafil

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Udenafil
Clinical data
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding93,9%
MetabolismLiver (mainlyCYP3A4)
Eliminationhalf-life7.3–12.1 hours
ExcretionBiliary
Identifiers
  • 3-(1-Methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzenesulfonamide
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC25H36N6O4S
Molar mass516.66 g·mol−1
3D model (JSmol)
  • O=C2\N=C(/Nc1c(nn(c12)C)CCC)c3cc(ccc3OCCC)S(=O)(=O)NCCC4N(C)CCC4
  • InChI=1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32) checkY
  • Key:IYFNEFQTYQPVOC-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

The drugudenafil is marketed under the trade nameZydena. It is within thePDE5 inhibitor class (which also includesavanafil,sildenafil,tadalafil, andvardenafil). Like other PDE5 inhibitors, it is used to treaterectile dysfunction. Udenafil was developed by Dong-A Pharmaceutical.[1] It has fairly rapid onset of action (peakplasma concentration after 1 to 1.5 hours), and has long duration of action (plasmahalf-life of 11 to 13 hours). Udenafil'spharmacokinetics allows once-daily dosage (in addition to on-demand use).[2] Typical doses are 100 and 200 mg. Udenafil is available in Korea, Russia, and the Philippines.[3] It has not yet been approved for use in the United States by theU.S. Food and Drug Administration.

References

[edit]
  1. ^Zydena (udenafil) product-information page. Dong-A Pharmaceutical. Retrieved on April 13, 2009.
  2. ^Kang SG, Kim JJ (April 2013)."Udenafil: efficacy and tolerability in the management of erectile dysfunction".Therapeutic Advances in Urology.5 (2):101–10.doi:10.1177/1756287212470019.PMC 3607490.PMID 23554845.
  3. ^"Zydena".Drugs.com.
Forerectile dysfunction
Prostaglandins (E)
PDE5 inhibitors
Alpha blockers
Dopamine agonists
Melanocortin agonists
Others
Forpremature ejaculation
SSRIs
Oxytocin antagonists
DRA/DRIs
PDE1
PDE2
PDE3
PDE4
PDE5
PDE7
PDE9
PDE10
PDE11
Non-selective
Unsorted
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