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UR-AK49

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
UR-AK49
Clinical data
Other namesUR-AK49
Identifiers
  • 3-cyclohexyl-N-[N'-[3-(1H-imidazol-5-yl)propyl]carbamimidoyl]propanamide
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H27N5O
Molar mass305.426 g·mol−1
3D model (JSmol)
  • c1c(nc[nH]1)CCCNC(=N)NC(=O)CCC2CCCCC2
  • InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22) checkY
  • Key:QBGKYFYOFBXHFM-UHFFFAOYSA-N checkY
  (verify)

UR-AK49 is a drug used in scientific research which acts as a potentantagonist for theNeuropeptide Y /Pancreatic polypeptidereceptorY4, and also as apartial agonist at thehistamine receptorsH1 andH2.[1] UR-AK49 is a pure antagonist at Y4 with no partial agonist effects, and although it is only slightly selective for Y4 over the relatedY1 andY5 receptors, as the first non-peptide Y4 antagonist developed UR-AK49 is expected to be useful in the study of this receptor and its role in the body.[2]

References

[edit]
  1. ^Xie SX, Kraus A, Ghorai P, Ye QZ, Elz S, Buschauer A, Seifert R (June 2006)."N1-(3-cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine (UR-AK57), a potent partial agonist for the human histamine H1- and H2-receptors"(PDF).The Journal of Pharmacology and Experimental Therapeutics.317 (3):1262–1268.doi:10.1124/jpet.106.102897.PMID 16554355.S2CID 26028129.
  2. ^Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence".Journal of Receptor and Signal Transduction Research.27 (4):217–233.doi:10.1080/10799890701505206.PMID 17885919.S2CID 26579625.
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H4
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