US 278 begins at an intersection withUS 59/US 71 in the town ofWickes in southwestern Arkansas.[1] From Wickes, US 278 continues eastward nearGillham Lake to an overlap withUS 70 throughDierks.[2] Continuing south, US 278 overlapsHighway 26 for 0.09 miles (0.14 km) atCenter Point.[3] Further south the route continues intoNashville. The route overlapsUS 371 and laterHighway 27 upon entering Nashville.
EnteringHempstead County, the highway winds through rural areas toOzan andWashington, before meetingUS 278 Business (US 278B) outsideHope.[4] The highway crosses overInterstate 30 (I-30) shortly after entering the city limits and overlapsHighway 29 andHighway 32. US 278/AR 29/AR 32 intersectUS 67 in east Hope. South of this junction AR 29 splits and US 278/AR 32 continues southeast. Further along this route, AR 32 turns southeast toWillisville and US 278 runs towardCamden.
The route intersectsHighway 53 in ruralNevada County, overlaps US 371 inRosston, and has a junction withHighway 57 upon enteringOuachita County.[5][6] InCamden, US 278 intersectsHighway 24 before it meetsUS 278B andUS 79B prior to overlappingUS 79. US 278 breaks from US 79 nearHarrell Field shortly before enteringEast Camden. US 278 continues intoCalhoun County andHampton and a junction withUS 371.[7] The east edge of town brings an intersection withHighway 274 as US 278 continues toHarrell andHighway 160 before enteringBradley County. Aside fromBanks, where US 278 has a junction withHighway 275, the route runs through rural country untilWarren, where US 278 almost entirely bypasses the city to the south while US 278B runs downtown, including a brief overlap withUS 63B. US 278 has an intersection withUS 63/AR 8 along the southern edge of Warren before serving as the eastern terminus for US 278B. Further east the highway intersectsHighway 172, which gives access to the Warren Prairie Natural Area just east of theDrew County line.[8]
The route continues toMonticello toMcGehee, where it meetsUS 65. US 278 overlaps US 65 southward for 16 miles (26 km) until they separate inLake Village. There, US 65 splits off and US 278 overlapsUS 82 east to theMississippi River, where US 82/US 278 crosses into Mississippi.
US 278 enters Alabama betweenGreenwood Springs, Mississippi, andSulligent, Alabama. As in Georgia, this and all U.S routes are partnered with state routes; however, there are few instances throughout the state where the state route number is posted. From the Mississippi state line toGuin, US 278 is paired withState Route 118. FromHamilton to the Georgia state line, US 278 is paired withState Route 74.
US 278 junctions withUS 431 atGadsden. The two routes overlap until they split atAttalla. US 278 overlapsUS 43 betweenHamilton andGuin. Prior to the completion ofCorridor X (FutureI-22), these two routes also overlappedUS 78 between these two towns; eastbound US 78 traveled in the same direction as westbound US 278.
In Atlanta, US 278 runs along Donald Lee Hollowell Parkway (Bankhead Highway), North Avenue, briefly along Piedmont Road and Ponce de Leon Avenue. Outsidethe Perimeter, US 278 runs along Covington Highway. InLithonia, Georgia, at the intersection with Turner Hill Road (SR 124), US 278 merges withI-20 for 15 miles (24 km). It leaves I-20 at exit 90, inCovington, Georgia.
US 278 is co-signed with a state route for its entire length in Georgia, as are all U.S. Highways in the state. From the Alabama line intoLithia Springs, it is co-signed withSR 6. From Lithia Springs through Atlanta, it is merged with US 78/SR 8. In Atlanta, US 278 merges further with other highways includingSR 10 andUS 23 before splitting off at Ponce de Leon Ave. and East Lake Road nearDecatur. InAvondale Estates,SR 12 is paired with US 278, all the way intoThomson. There, US 278 merges with US 78/SR 10 to the South Carolina line.
Upon reaching Hardeeville, the route heads eastward toward theAtlantic with major new developments lining the spine of the road from Hardeeville throughSun City andBluffton before crossing over the bridge toHilton Head Island. US 278 ends at US 278 Business on the southern portion of Hilton Head Island, just outsideSea Pines Plantation.
Alabama rerouted a section of US 278 in Guin over a section ofSR 118 in 1995. At the same time, South Carolina rerouted the highway inRidgeland overUS 17 andSC 88.[15]
Alabama relocated US 278 inGadsden in 2000.[18] Until early 2005, US 278 was only signed in Mississippi from the Alabama state line to US 45 west ofAmory. US 278 in western Alabama was formerly routed through Haleyville via current SR 195 and SR 129.[citation needed] In 2014, Alabama relocated US 278 inCullman.[19]
^Planning and Research Division (2000).General Highway Map, Polk County, Arkansas(PDF) (Map). 1:62,500. Arkansas State Highway and Transportation Department. Archived fromthe original(PDF) on March 13, 2012. RetrievedDecember 28, 2011.
^Planning and Research Division (2000).General Highway Map, Howard County, Arkansas(PDF) (Map). 1:62,500. Arkansas State Highway and Transportation Department. Archived fromthe original(PDF) on March 13, 2012. RetrievedDecember 28, 2011.
^Planning and Research Division (2011).General Highway Map, Nevada County, Arkansas(PDF) (Map). 1:62,500. Arkansas State Highway and Transportation Department. Archived fromthe original(PDF) on July 18, 2011. RetrievedDecember 31, 2011.
^Planning and Research Division (2008).General Highway Map, Ouachita County, Arkansas(PDF) (Map). 1:62,500. Arkansas State Highway and Transportation Department. Archived fromthe original(PDF) on September 23, 2015. RetrievedDecember 31, 2011.
^Planning and Research Division (1999).General Highway Map, Calhoun County, Arkansas(PDF) (Map). 1:62,500. Arkansas State Highway and Transportation Department. Archived fromthe original(PDF) on January 27, 2021. RetrievedJanuary 9, 2012.
^Planning and Research Division (2008).General Highway Map, Bradley County, Arkansas(PDF) (Map). 1:62,500. Arkansas State Highway and Transportation Department. RetrievedJanuary 9, 2012.
^"Minutes of the Meeting of the Arkansas State Highway Commission, August 6, 1997"(PDF). p. 963. Archived fromthe original(PDF) on July 21, 2019. RetrievedMarch 3, 2015.WHEREAS, the State of Mississippi has expressed interest in extending U.S. 278, which presently ends at Tupelo, westward into Arkansas on a temporary location, utilizing the U.S. 82 river crossing, with an ultimate alignment over the future Great River Bridge and connecting roadways;
^Special Committee on U.S. Route Numbering (May 29, 2014)."Report to SCOH" (Report). Washington, DC: American Association of State Highway and Transportation Officials. Archived fromthe original(DOCX) on February 26, 2020. RetrievedJune 3, 2022.