Chemical structure oftropane which forms the core of tropane alkaloidsChemical structure and phylogeny oftropane alkaloids. Displayed are 3 chemical compounds that occur as natural products in 5 plant species
All threeacetylcholine-inhibiting chemicals can also be found in the leaves, stems, and flowers in varying, unknown amounts inBrugmansia (angel trumpets), a relative ofDatura. The same is also true of many other plants belonging to subfamilySolanoideae of theSolanaceae, the alkaloids being concentrated particularly in the leaves and seeds. However, the concentration of alkaloids can vary greatly, even from leaf to leaf and seed to seed.[14][15]
The biosynthesis of the tropane alkaloids have attracted intense interest because of their high physiological activity as well as the presence of the bicyclictropane core.[17]
Final stages in the pathway for the biosynthesis of the tropane alkaloid cocaine.
^Rätsch C (2005).The Encyclopedia of Psychoactive Plants: Ethnopharmacology and Its Applications. Park Street Press.ISBN978-0-89281-978-2.
^Grynkiewicz G, Gadzikowska M (2008). "Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs".Pharmacological Reports.60 (4):439–463.PMID18799813.
^Volgin AD, Yakovlev OA, Demin KA, Alekseeva PA, Kyzar EJ, Collins C, et al. (16 October 2018). "Understanding Central Nervous System Effects of Deliriant Hallucinogenic Drugs through Experimental Animal Models".ACS Chemical Neuroscience.10 (1):143–154.doi:10.1021/acschemneuro.8b00433.PMID30252437.S2CID52824516.
^Hawkes JG, Lester RN, Skelding AD, eds. (1979).The Biology and Taxonomy of the Solanaceae. Linnean Society Symposium Series. Vol. 7. Academic Press for the Linnean Society of London.ISBN978-0-12-333150-2.
^Eich E (2008).Solanaceae and Convolvulaceae: Secondary Metabolites – Biosynthesis, Chemotaxonomy, Biological and Economic Significance (A Handbook). Berlin Heidelberg: Springer-Verlag.ISBN978-3-540-74541-9.
