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Trimerelysin II (EC 3.4.24.53,Trimeresurus metalloendopeptidase II,proteinase H2,H2-proteinase) is anenzyme.^[1]^[2] This enzymecatalyses the followingchemical reaction

Cleavage of Asn³-Gln, His¹⁰-Leu and Ala¹⁴-Leu in theinsulin B chain, and the bond Z-Gly-Pro-Leu-Gly-Pro in a small molecule substrate ofmicrobial collagenase

Thisendopeptidase is present in thevenom of thehabu snake (Trimeresurus flavoviridis).

References

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^Takahashi T, Ohsaka A (February 1970). "Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity".Biochimica et Biophysica Acta (BBA) - Enzymology.198 (2):293–307.doi:10.1016/0005-2744(70)90062-8.PMID 4984550.
^Takeya H, Arakawa M, Miyata T, Iwanaga S, Omori-Satoh T (July 1989). "Primary structure of H2-proteinase, a non-hemorrhagic metalloproteinase, isolated from the venom of the habu snake, Trimeresurus flavoviridis".Journal of Biochemistry.106 (1):151–7.doi:10.1093/oxfordjournals.jbchem.a122805.PMID 2777746.

External links

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Trimerelysin+II at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

v t e Proteases:metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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Category:

EC 3.4.24

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