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Trichosanthin

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Identifiers
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Alt. namesα-Trichosanthin
CAS number60318-52-7
UniProtP09989
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StructuresSwiss-model
DomainsInterPro

Trichosanthin is aribosome-inactivating protein.[1][2] It is derived fromTrichosanthes kirilowii.[3] It is also anabortifacient.[4]

References

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  1. ^Too PH, Ma MK, Mak AN, et al. (February 2009)."The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome".Nucleic Acids Res.37 (2):602–10.doi:10.1093/nar/gkn922.PMC 2632931.PMID 19073700.
  2. ^Shaw PC, Lee KM, Wong KB (May 2005). "Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties".Toxicon.45 (6):683–9.Bibcode:2005Txcn...45..683S.doi:10.1016/j.toxicon.2004.12.024.PMID 15804517.
  3. ^Zhao J, Ben LH, Wu YL, et al. (July 1999)."Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors".J. Exp. Med.190 (1):101–11.doi:10.1084/jem.190.1.101.PMC 2195565.PMID 10429674.
  4. ^Li MX, Yeung HW, Pan LP,Chan SI (November 1991)."Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro".Nucleic Acids Res.19 (22):6309–12.doi:10.1093/nar/19.22.6309.PMC 329144.PMID 1659689.

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