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Trendione

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Trendione
Clinical data
Other namesRU-2065; Trenavar; Triendione; Estra-4,9,11-triene-3,17-dione
Drug classAndrogen;Anabolic steroid;Progestogen
Identifiers
  • (8S,13S,14S)-13-Methyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC18H20O2
Molar mass268.356 g·mol−1
3D model (JSmol)
  • C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CCC2=O
  • InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-16H,2-7H2,1H3/t15-,16+,18+/m1/s1
  • Key:KBSXJBBFQODDTQ-RYRKJORJSA-N

Trendione (developmental code nameRU-2065; nicknameTrenavar), also known asestra-4,9,11-triene-3,17-dione, is anandrogen prohormone as well asmetabolite of theanabolic steroidtrenbolone.[1][2][3][4][5] Trendione is to trenbolone asandrostenedione is totestosterone.[6] The compound is inactive itself, showing more than 100-fold loweraffinity for theandrogen andprogesterone receptors than trenbolone.[7][8] It is adesigner steroid and has been sold on the internet as a "nutritional supplement".[1] Trendione is listed in theUnited StatesDesigner Anabolic Steroid Control Act of 2014.[1]

See also

[edit]

References

[edit]
  1. ^abcLiane BJ, Magee C (October 2016)."Guerilla Warfare on the Pancreas? A Case of Acute Pancreatitis From a Supplement Known to Contain Anabolic-Androgenic Steroids".Mil Med.181 (10):e1395 –e1397.doi:10.7205/MILMED-D-15-00575.PMID 27753588.
  2. ^Yarrow JF, McCoy SC, Borst SE (June 2010). "Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity".Steroids.75 (6):377–89.doi:10.1016/j.steroids.2010.01.019.PMID 20138077.S2CID 205253265.
  3. ^Metzler M (April 1989). "Metabolism of some anabolic agents: toxicological and analytical aspects".J. Chromatogr.489 (1):11–21.doi:10.1016/s0378-4347(00)82880-7.PMID 2745641.
  4. ^Yarrow JF, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, VanPelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE (April 2011)."17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate".Am. J. Physiol. Endocrinol. Metab.300 (4): E650–60.doi:10.1152/ajpendo.00440.2010.PMC 6189634.PMID 21266670.
  5. ^Spranger B, Metzler M (April 1991). "Disposition of 17 beta-trenbolone in humans".J. Chromatogr.564 (2):485–92.doi:10.1016/0378-4347(91)80517-g.PMID 1874853.
  6. ^Advances in Agronomy. Elsevier. 13 April 2007. pp. 16–.ISBN 978-0-08-048819-6.
  7. ^Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH (December 2000). "Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor".APMIS.108 (12):838–46.doi:10.1111/j.1600-0463.2000.tb00007.x.PMID 11252818.S2CID 22776408.
  8. ^Delettré J, Mornon JP, Lepicard G, Ojasoo T, Raynaud JP (January 1980). "Steroid flexibility and receptor specificity".J. Steroid Biochem.13 (1):45–59.doi:10.1016/0022-4731(80)90112-0.PMID 7382482.


ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists


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