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Trans-cinnamate 4-monooxygenase

From Wikipedia, the free encyclopedia
Class of enzymes
trans-cinnamate 4-monooxygenase
Identifiers
EC no.1.14.14.91
CAS no.9077-75-2
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BRENDABRENDA entry
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Inenzymology, atrans-cinnamate 4-monooxygenase (EC1.14.14.91) is anenzyme thatcatalyzes thechemical reaction

trans-cinnamate + NADPH + H+ + O2{\displaystyle \rightleftharpoons } 4-hydroxycinnamate + NADP+ + H2O

The 4substrates of this enzyme aretrans-cinnamate,NADPH,H+, andO2, whereas its 3products are4-hydroxycinnamate,NADP+, andH2O. This enzyme participates inphenylalanine metabolism andphenylpropanoid biosynthesis. It employs onecofactor,heme.

This enzyme belongs to the family ofoxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor.

Nomenclature

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Thesystematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include:

  • cinnamic acid 4-hydroxylase,
  • oxygenase, cinnamate 4-mono-,
  • CA4H (gene name),
  • CYP73A1 (gene name),
  • cytochrome P450 cinnamate 4-hydroxylase,
  • cinnamate 4-hydroxylase,
  • cinnamate 4-monooxygenase,
  • cinnamate hydroxylase,
  • cinnamic 4-hydroxylase,
  • cinnamic acid 4-monooxygenase,
  • cinnamic acid p-hydroxylase,
  • hydroxylase, cinnamate 4-,
  • t-cinnamic acid hydroxylase,
  • trans-cinnamate 4-hydroxylase, and
  • trans-cinnamic acid 4-hydroxylase.

References

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Further reading

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CYP1
CYP2
CYP3 (CYP3A)
CYP4
CYP5-20
CYP21-49
CYP51-69
CYP71-99
CYP101-281
CYP301-499
CYP501-699
CYP701-999
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