Benzhydryl compound
Pharmaceutical compound
Tolterodine , sold under the brand nameDetrol among others, is amedication used to treatfrequent urination ,urinary incontinence , orurinary urgency .[ 5] [ 6] [ 6] [ 7]
Common side effects include headache, dry mouth, constipation, and dizziness.[ 6] angioedema ,urinary retention , andQT prolongation .[ 6] pregnancy andbreastfeeding are of unclear safety.[ 5] [ 8] blocking muscarinic receptors in thebladder thus decreasing bladder contractions.[ 6]
Tolterodine was approved for medical use in 1998.[ 6] generic medication .[ 5] million prescriptions.[ 9] [ 10]
Detrusor overactivity (DO, contraction of the muscular bladder wall) is the most common form of urinary incontinence (UI) in older adults.[medical citation needed It is characterized by uninhibited bladder contractions causing an uncontrollable urge to void.[medical citation needed Urinary frequency, urge incontinence and nocturnal incontinence occur.[medical citation needed Abnormal bladder contractions that coincide with the urge to void can be measured byurodynamic studies .[medical citation needed Treatment is bladder retraining,[ 11] [unreliable medical source? pelvic floor therapy or with drugs that inhibit bladder contractions such asoxybutynin and tolterodine.[medical citation needed
Known side effects:
The following reactions have been reported in people who have taken tolterodine since it has become available:
Tolterodine is not recommended for use in people withmyasthenia gravis andangle closure glaucoma .
Tolterodine acts on M2 and M3 [ 13] muscarinic receptors whereas olderantimuscarinic treatments for overactive bladder act more specifically on M3 receptors.[medical citation needed
Tolterodine, although it acts on all types of receptors, has fewer side effects thanoxybutynin (M3 and M1 selective, but more so in the parotid than in the bladder) as tolterodine targets the bladder more than other areas of the body.[medical citation needed
Society and culture [ edit ] It is marketed byPfizer in Canada and the United States under the brand name Detrol, while in Indonesia it is marketed under the brand name Detrusitol. In Egypt it is also found under the trade names Tolterodine by Sabaa and Incont L.A. by Adwia.
In the US, Detrol is marketed byViatris after Upjohn was spun off from Pfizer.[ 14] [ 15] [ 16]
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