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| Clinical data | |
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| Trade names | Tinactin |
| Other names | 2-NaphthylN-methyl-N-(3-tolyl)thionocarbamate[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682617 |
| ATC code | |
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| ECHA InfoCard | 100.017.516 |
| Chemical and physical data | |
| Formula | C19H17NOS |
| Molar mass | 307.41 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 110 to 111.5 °C (230.0 to 232.7 °F) |
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Tolnaftate (INN),[1] sold under the brand nameTAGRID, among others, is a syntheticthiocarbamate used as ananti-fungal agent that may be soldwithout medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, andliquid aerosol.[2] Tolnaftate is used to treat fungal conditions such asjock itch,athlete's foot andringworm.[2]
Although the exact mechanism of action is not entirely known, it is believed to inhibitsqualene epoxidase,[3] an important enzyme in the biosynthetic pathway ofergosterol (a key component of the fungal cell membrane) in a similar way toterbinafine.[4]
Tolnaftate has been found to be generally slightly less effective thanazoles when used to treattinea pedis (athlete's foot). It is, however, useful when dealing withringworm, especially when passed from pets to humans.[5]
Side effects that may occur include:[6]
Less severe side effects include:[6]