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Tolciclate

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Tolciclate
Space-filling model of the tolciclate molecule
Clinical data
Other namesO-(1,2,3,4-Tetrahydro-1,4-methanonaphthalen-6-yl)m,N-dimethylthiocarbanilate[1]
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • O-Tricyclo[6.2.1.02,7]undeca-2,4,6-trien-4-yl methyl(3-methylphenyl)carbamothioate
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
ECHA InfoCard100.051.611Edit this at Wikidata
Chemical and physical data
FormulaC20H21NOS
Molar mass323.45 g·mol−1
3D model (JSmol)
  • Cc1cccc(c1)N(C)C(=S)Oc2ccc3c(c2)C4CCC3C4
  • InChI=1S/C20H21NOS/c1-13-4-3-5-16(10-13)21(2)20(23)22-17-8-9-18-14-6-7-15(11-14)19(18)12-17/h3-5,8-10,12,14-15H,6-7,11H2,1-2H3 ☒N
  • Key:CANCCLAKQQHLNK-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tolciclate (INN)[1]: 9  is anantifungal medication.[2][3]

See also

[edit]

References

[edit]
  1. ^ab"International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary names: List 15"(PDF). World Health Organization. 1975. Retrieved12 November 2016.
  2. ^Ryder NS, Frank I, Dupont MC (May 1986)."Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate".Antimicrobial Agents and Chemotherapy.29 (5):858–60.doi:10.1128/aac.29.5.858.PMC 284167.PMID 3524433.
  3. ^Bianchi A, Monti G, de Carneri I (September 1977)."Tolciclate: further antimycotic studies".Antimicrobial Agents and Chemotherapy.12 (3):429–30.doi:10.1128/aac.12.3.429.PMC 429931.PMID 907333.
Wall/
membrane
Ergosterol
inhibitors
Azoles (lanosterol 14α-
demethylase
inhibitors)
Imidazoles
Triazoles
Thiazoles
Polyene antimycotics
(ergosterol binding)
Squalene monooxygenase
inhibitors
Allylamines
Benzylamines
Others
β-glucan synthase
inhibitors
Intracellular
Pyrimidine analogues/
thymidylate synthase inhibitors
Mitotic inhibitors
Aminoacyl tRNA synthetase inhibitors
Others
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