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Togavirin (EC 3.4.21.90,Sindbis virus protease,Sindbis virus core protein,NsP2 proteinase) is anenzyme.^[1]^[2]^[3] This enzymecatalyses the followingchemical reaction

Autocatalytic release of the core protein from theN-terminus of thetogavirus structural polyprotein byhydrolysis of a -Trp-Ser- bond

This enzyme is isolated from theSindbis andSemliki forest togaviruses.

References

^Kräusslich HG, Wimmer E (1988). "Viral proteinases".Annual Review of Biochemistry.57:701–54.doi:10.1146/annurev.bi.57.070188.003413.PMID 3052288.
^Strauss EG, De Groot RJ, Levinson R, Strauss JH (December 1992)."Identification of the active site residues in the nsP2 proteinase of Sindbis virus".Virology.191 (2):932–40.doi:10.1016/0042-6822(92)90268-t.PMC 7131396.PMID 1448929.
^Tong L, Wengler G, Rossmann MG (March 1993). "Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures".Journal of Molecular Biology.230 (1):228–47.doi:10.1006/jmbi.1993.1139.PMID 8450538.

Togavirin at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

v t e Endopeptidases:serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors:Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis:Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Otherimmune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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