Tissue factor pathway inhibitor (orTFPI) is a single-chain polypeptide which can reversibly inhibitfactor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit theFVIIa-tissue factor complex.TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.
The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. A similar gene, termedTFPI2, has been identified onchromosome 7, atlocus 7q21.3; in addition to TFPI activity, its product also hasretinal pigment epithelial cell growth-promoting properties.
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