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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Formula | C15H17NS2 |
| Molar mass | 275.43 g·mol−1 |
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Tipepidine (INN; also known astipepidine hibenzate (JAN); brand namesAsverin,Antupex,Asvelik,Asvex,Bitiodin,Cofdenin A,Hustel,Nodal, andSotal) is asynthetic, non-opioidantitussive andexpectorant of thethiambutene class.[1][2] It acts as aninhibitor ofG protein-coupled inwardly-rectifying potassium channels (GIRKs).[3] The drug was discovered in the 1950s,[4] and was developed inJapan in 1959.[5] It is used as thehibenzate andcitrate salts.[1][5]
The usual dose is 20 mg every 4–6 hours.[citation needed] Possibleside effects of tipepidine, especially inoverdose, may includedrowsiness,vertigo,delirium,disorientation,loss of consciousness, andconfusion.[5]
Tipepidine has been investigated as a potentialpsychiatric drug. It is being investigated indepression,[3][6][7]obsessive-compulsive disorder,[8] andattention-deficit hyperactivity disorder (ADHD).[9][10][11] Through inhibition of GIRK channels, tipepidine increasesdopamine levels in thenucleus accumbens, but withoutincreasing locomotor activity or producingmethamphetamine-likebehavioral sensitization, and this action appears to be at least partly responsible for itsantidepressant-like effects in rodents.[12][13]
