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Timepidium bromide

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Chemical compound
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Pharmaceutical compound
Timepidium bromide
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
SC, IM, IV
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethylpiperidinium bromide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC17H22BrNOS2
Molar mass400.39 g·mol−1
3D model (JSmol)
  • C[N+]1(CC(CC(=C(C2=CC=CS2)C3=CC=CS3)C1)OC)C.[Br-]
  • InChI=1S/C17H22NOS2.BrH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1 ☒N
  • Key:QTSXMEPZSHLZFF-UHFFFAOYSA-M ☒N
 ☒NcheckY (what is this?)  (verify)

Timepidium bromide (INN) is ananticholinergic. It is used in the symptomatic treatment of visceral spasms.[1] It is also used to relieve pain associated with various gastrointestinal disorders.[2] The quaternary nitrogen prevents it from crossing theblood brain barrier, so it is peripherally acting with no central side effects.

The same compoundsans the quaternary methyl group and the methoxy ether is calledtipepidine.[3]

References

[edit]
  1. ^"Timepidium bromide: Indication, Dosage, Side Effect, Precaution | MIMS Malaysia".www.mims.com. Retrieved2021-07-05.
  2. ^"Timepidium Bromide Tablets 30mg SAWAI 100 Tablets|Natural Pharmacy".www.mimaki-family-japan.com. Retrieved2021-07-05.
  3. ^Shah R, Verma PK (December 2018)."Therapeutic importance of synthetic thiophene".Chemistry Central Journal.12 (1) 137.doi:10.1186/s13065-018-0511-5.PMC 6768136.PMID 30564984.
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium

compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)


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