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| Clinical data | |
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| Trade names | Surgam, Surgamyl, Tiaprofen, others |
| Other names | 5-Benzoyl-α-methyl-2-thiopheneacetic acid |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | 90% |
| Metabolism | 10% liver |
| Eliminationhalf-life | 1.5-2.5h |
| Excretion | 50-80% urine |
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| ECHA InfoCard | 100.046.649 |
| Chemical and physical data | |
| Formula | C14H12O3S |
| Molar mass | 260.31 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Tiaprofenic acid is anonsteroidal anti-inflammatory drug (NSAID) of thearylpropionic acid (profen) class, used to treat pain, especiallyarthritic pain. The typical adult dose is 300 mg twice daily. It is not recommended for children.
Long-term use of tiaprofenic acid is associated with severecystitis, roughly 100 times more commonly than other NSAIDs.[1] It is contraindicated in patients with cystitis and urinary tract infections. It is sparingly metabolised in theliver to two inactive metabolites. Most of the drug is eliminated unchanged in theurine. Renal disease impairs excretion, and should be used cautiously in renal disease.
It was patented in 1969 and approved for medical use in 1981.[2] It is available ingeneric formulations. A sustained-release preparation is available. It is anisomer ofSuprofen.
| pyrazolones / pyrazolidines | |
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| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
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| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
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