TheThorpe reaction is achemical reaction described as a self-condensation ofaliphaticnitriles catalyzed bybase to formenamines.[1][2][3] The reaction was discovered byJocelyn Field Thorpe.
TheThorpe–Ziegler reaction (named afterJocelyn Field Thorpe andKarl Ziegler), orZiegler method, is theintramolecular modification with a dinitrile as a reactant and a cyclicketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to theDieckmann condensation.[3]
