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Thonzylamine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Thonzylamine
Clinical data
Other namesNeohetramine
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.001.913Edit this at Wikidata
Chemical and physical data
FormulaC16H22N4O
Molar mass286.379 g·mol−1
3D model (JSmol)
  • n1cccnc1N(CCN(C)C)Cc2ccc(OC)cc2
  • InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3 checkY
  • Key:GULNIHOSWFYMRN-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Thonzylamine (orneohetramine)[1] is anantihistamine andanticholinergic used as anantipruritic.

Synthesis

[edit]
Thonzylamine synthesis: H. L. Friedman and A, V. Tolstouhov,U.S. patent 2,465,865 (1949).

See also

[edit]

References

[edit]
  1. ^Arminio JJ, Sweet CC (December 1949). "The prophylaxis and treatment of the common cold with neohetramine (thonzylamine hydrochloride)".Industrial Medicine & Surgery.18 (12):509–11.PMID 15393969.
Antihistamines fortopical use
Anesthetics for topical use
Others
Decongestants and other nasal preparations (R01)
Topical
Sympathomimetics, plain
Antiallergic agents,
excluding corticosteroids
Corticosteroids
Other nasal preparations
Combination products
Systemic use:
Sympathomimetics
Benzimidazoles(*)
Diarylmethanes
Ethylenediamines
Tricyclics
Others
Fortopical use
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)
nAChRsTooltip Nicotinic acetylcholine receptors
Agonists
(andPAMsTooltip positive allosteric modulators)
Antagonists
(andNAMsTooltip negative allosteric modulators)
Precursors
(andprodrugs)
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
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Retrieved from "https://en.wikipedia.org/w/index.php?title=Thonzylamine&oldid=1247281064"
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