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| Clinical data | |
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| Other names | TP; 4-Thioproscaline; 4-TP; 3,5-Dimethoxy-4-propylthiophenethylamine; 4-Propylthio-3,5-dimethoxyphenethylamine |
| Routes of administration | Oral[1] |
| Drug class | Serotonergic psychedelic;Hallucinogen |
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| Pharmacokinetic data | |
| Onset of action | >2 hours[1] |
| Duration of action | 10–15 hours[1] |
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| Chemical and physical data | |
| Formula | C13H21NO2S |
| Molar mass | 255.38 g·mol−1 |
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Thioproscaline (TP), or4-thioproscaline (4-TP), also known as3,5-dimethoxy-4-propylthiophenethylamine, is apsychedelic drug of thephenethylamine andscaline families related tomescaline.[1][2][3][4] It is theanalogue ofproscaline in which thepropoxy group at the 4 position has been replaced with apropylthio group.[1][2][3]
In his bookPiHKAL (Phenethylamines I Have Known and Loved) and other publications,Alexander Shulgin lists thioproscaline's dose as 20 to 25 mgorally and itsduration as 10 to 15 hours.[1][2][3] Itsonset is more than 2 hours.[1] The drug has approximately 10 to 16 times thepotency of mescaline.[2][3][4][1] The effects of thioproscaline have been reported to include extremely richclosed-eyeimagery, quite a bit ofopen-eye visuals,body load, body heaviness, heavy pressure at the back of the neck, feeling vulnerable,dizziness, andhyperreflexia.[1][4] It was remarked that thepsychoactive effects did not seem worth the physicalside effects, although it was suggested that lower doses might be better.[1][4]
Thechemical synthesis of thioproscaline has been described.[1][4]
Thioproscaline was first described in thescientific literature byAlexander Shulgin andPeyton Jacob III in 1984.[4] Subsequently, it was described in greater detail by Shulgin inPiHKAL in 1991.[1] The drug is not acontrolled substance inCanada as of 2025.[5]
