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| Formula | C31H39NO4S |
| Molar mass | 521.72 g·mol−1 |
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Thienorphine is a very potent, extremely long-acting, orally-activeopioidanalgesic with mixedagonist–antagonist properties which was developed by the Beijing Institute of Pharmacology and Toxicology as a potential non-addictive analgesic and treatment foropioid dependence.[1][2][3][4] It is a high-affinity, balancedligand of theμ- (Ki = 0.22 nM),δ- (Ki = 0.69 nM), andκ-opioid receptors (Ki = 0.14 nM), behaving as apartial agonist of the μ- (Emax = 19%–28%) and κ-opioid receptors (Emax = 65–75%) and as anantagonist of the δ-opioid receptor.[5][6][7] It also possesses relatively low affinity for thenociceptin receptor (Ki = 36.5 nM), where it acts as an antagonist.[7]
