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Theodrenaline

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From Wikipedia, the free encyclopedia

Chemical compound used as a cardiac stimulant

Pharmaceutical compound

Theodrenaline
Clinical data

Other names	Noradrenalinoethyltheophylline; Noradrenaline theophylline
ATC code	C01CA23 (WHO)
Identifiers
IUPAC name (RS)-7-(2-{[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino}ethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
CAS Number	13460-98-5
PubChemCID	71857
DrugBank	DB12927^Y
ChemSpider	64874^N
UNII	RW8PD99T8G
KEGG	D07155^Y
ChEBI	CHEBI:135580
ChEMBL	ChEMBL2107608
CompTox Dashboard(EPA)	DTXSID40864406
Chemical and physical data
Formula	C₁₇H₂₁N₅O₅
Molar mass	375.385 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Cn1c2c(c(=O)n(c1=O)C)n(cn2)CCNCC(c3ccc(c(c3)O)O)O
InChI InChI=1S/C17H21N5O5/c1-20-15-14(16(26)21(2)17(20)27)22(9-19-15)6-5-18-8-13(25)10-3-4-11(23)12(24)7-10/h3-4,7,9,13,18,23-25H,5-6,8H2,1-2H3^N Key:WMCMJIGLYZDKRN-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Theodrenaline (INNTooltip International Nonproprietary Name), also known asnoradrenalinoethyltheophylline or asnoradrenaline theophylline, is a chemical linkage ofnorepinephrine (noradrenaline) andtheophylline used as acardiac stimulant.^[1]^[2] It is sometimes combined withcafedrine.^[1]^[2]

References

[edit]

^^a ^bUsichenko TI, Foellner S, Gruendling M, Feyerherd F, Lehmann C, Wendt M, Pavlovic D (March 2006)."Akrinor-induced relaxation of pig coronary artery in vitro is transformed into alpha1-adrenoreceptor-mediated contraction by pretreatment with propranolol".Journal of Cardiovascular Pharmacology.47 (3):450–5.doi:10.1097/01.fjc.0000211710.87863.89.PMID 16633089.S2CID 20221167.
^^a ^bSchweizerischer Apotheker-Verein (2000).Index Nominum 2000: International Drug Directory. Index nominum. Medpharm Scientific Publishers. pp. 157, 1011.ISBN 978-3-88763-075-1. Retrieved29 August 2024.

Cardiac stimulants excluding cardiac glycosides (C01C)

Adrenergic and
dopaminergic agents

Adrenergic agonists

α	Denopamine Metaraminol Methoxamine Midodrine Norfenefrine Oxedrine Phenylephrine
β	Arbutamine Dobutamine Isoprenaline Prenalterol
mixed	Amezinium metilsulfate Droxidopa Epinephrine # Etilefrine Norepinephrine

Dopamine agonists

Fenoldopam

Both

Unknown/ungrouped

Phosphodiesterase inhibitors (PDE3I)

Other cardiac stimulants

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Purine receptor modulators

Receptor
(ligands)

P0 (adenine)

Agonists:8-Aminoadenine
Adenine

P1
(adenosine)

P2
(nucleotide)

P2X
(ATPTooltip Adenosine triphosphate)

P2Y

Transporter
(blockers)

CNTsTooltip Concentrative nucleoside transporters	6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone
ENTsTooltip Equilibrative nucleoside transporters	Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline
PMATTooltip Plasma membrane monoamine transporter	Decynium-22

Enzyme
(inhibitors)

XOTooltip Xanthine oxidase	Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat
Others	Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others