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| Names | |
|---|---|
| IUPAC name 9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3,5,8(34),9,11,18,20,22(33),24(32),25,27(31),35-dodecaene | |
| Identifiers | |
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3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.208.615 |
| EC Number |
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| KEGG |
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| UNII | |
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| Properties | |
| C38H42N2O6 | |
| Molar mass | 622.74988 |
| Hazards | |
| GHS labelling:[1] | |
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| Danger | |
| H300 | |
| P264,P270,P301+P316,P301+P317,P321,P330,P405,P501 | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Tetrandrine, abis-benzylisoquinoline alkaloid, is acalcium channel blocker.[1] It is isolated from the plantStephania tetrandra,[2] and other Chinese and Japanese herbs.
It has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation ofmast cells. It has aquinidine-like anti-arrhythmic effect. It hasvasodilatory properties and can therefore reduce blood pressure.[3] Tetrandrine may have potential use for the treatment of liver disease[4] and liver cancer.[5][6][7] Tetrandrine has potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva followingtrabeculectomy or in patients with severeconjunctival inflammation.[8] Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment oflung silicosis, liver cirrhosis, and rheumatoid arthritis.[9] Tetrandrine has also been shown to inhibit entry ofEbola virus into host cellsin vitro and showed therapeutic efficacy against Ebola in preliminary studies on mice.[10][1] Tetrandrine has also been studied and patented as a possible treatment fortinnitus.[11][12][13]
Tetrandrine is biosynthesized from a free radical coupled dimerization ofS-N-methylcoclaurine:[14]
Synonyms include fanchinine, hanfangchin A, NSC 77037, (S,S)-(+)-tetrandrine, sinomenine A, TTD, tetrandrin, d-tetrandrine, and GW-201.[15][13]
