Movatterモバイル変換

[0]ホーム

Jump to content

Testicular receptor 2

Edit links

From Wikipedia, the free encyclopedia

Human protein-coding gene

NR2C1

Identifiers

Aliases

NR2C1, TR2, Testicular receptor 2, nuclear receptor subfamily 2 group C member 1

External IDs

OMIM:601529;MGI:1352465;HomoloGene:55731;GeneCards:NR2C1;OMA:NR2C1 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q22	Start	95,020,229bp^[1]
Band	12q22	End	95,073,628bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 C2\|10 48.81 cM	Start	93,983,885bp^[2]
Band	10 C2\|10 48.81 cM	End	94,033,073bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar hemisphere

right hemisphere of cerebellum

left lobe of thyroid gland

right lung

tibial nerve

muscle of thigh

sural nerve

right lobe of thyroid gland

right lobe of liver

gastric mucosa

Top expressed in

spermatid

spermatocyte

seminal vesicula

corneal stroma

otic vesicle

male urethra

secondary oocyte

genital tubercle

seminiferous tubule

tail of embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	sequence-specific DNA binding protein homodimerization activity DNA-binding transcription factor activity zinc ion binding histone deacetylase binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding steroid hormone receptor activity DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific signaling receptor activity
Cellular component	PML body nucleoplasm nucleus
Biological process	regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of retinoic acid receptor signaling pathway transcription initiation from RNA polymerase II promoter negative regulation of transcription, DNA-templated steroid hormone mediated signaling pathway signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


7181


22025

Ensembl


ENSG00000120798


ENSMUSG00000005897

UniProt


P13056


Q505F1

RefSeq (mRNA)


NM_001032287 NM_001127362 NM_003297


NM_011629

RefSeq (protein)


NP_001027458 NP_001120834 NP_003288 NP_003288.2


NP_035759

Location (UCSC)

Chr 12: 95.02 – 95.07 Mb

Chr 10: 93.98 – 94.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Thetesticular receptor 2 (TR2) also known asNR2C1 (nuclear receptor subfamily 2, group C, member 1) isprotein that in humans is encoded by theNR2C1gene.^[5]^[6] TR2 is a member of thenuclear receptor family oftranscription factors.

Interactions

[edit]

Testicular receptor 2 has been shown tointeract with:

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000120798 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000005897 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1".
^Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (Dec 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains".Biochemical and Biophysical Research Communications.165 (2):735–41.Bibcode:1989BBRC..165..735C.doi:10.1016/S0006-291X(89)80028-2.PMID 2597158.
^Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3".The Prostate.57 (2):129–33.doi:10.1002/pros.10282.PMID 12949936.S2CID 24134119.
^Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002)."Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor".The Journal of Biological Chemistry.277 (37):33571–9.doi:10.1074/jbc.M203531200.PMID 12093804.
^Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2".Biochemical and Biophysical Research Communications.310 (2):384–90.Bibcode:2003BBRC..310..384L.doi:10.1016/j.bbrc.2003.08.145.PMID 14521922.
^^a ^bFranco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase".Molecular and Cellular Endocrinology.206 (1–2):1–12.doi:10.1016/S0303-7207(03)00254-5.PMID 12943985.S2CID 19487189.
^^a ^bFranco PJ, Farooqui M, Seto E, Wei LN (Aug 2001)."The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases".Molecular Endocrinology.15 (8):1318–28.doi:10.1210/mend.15.8.0682.PMID 11463856.

Chang C, Kokontis J (Sep 1988). "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis".Biochemical and Biophysical Research Communications.155 (2):971–7.Bibcode:1988BBRC..155..971C.doi:10.1016/S0006-291X(88)80591-6.PMID 3421977.
Lin DL, Wu SQ, Chang C (Apr 1998). "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily".Endocrine.8 (2):123–34.doi:10.1385/ENDO:8:2:123.PMID 9704569.S2CID 23712655.
Lee CH, Chinpaisal C, Wei LN (Sep 1998)."A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4".The Journal of Biological Chemistry.273 (39):25209–15.doi:10.1074/jbc.273.39.25209.PMID 9737983.
Lee CH, Chinpaisal C, Wei LN (Nov 1998)."Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2".Molecular and Cellular Biology.18 (11):6745–55.doi:10.1128/mcb.18.11.6745.PMC 109258.PMID 9774688.
Yu Z, Lee CH, Chinpaisal C, Wei LN (Oct 1998)."A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2".The Journal of Endocrinology.159 (1):53–60.doi:10.1677/joe.0.1590053.PMID 9795341.
Franco PJ, Farooqui M, Seto E, Wei LN (Aug 2001)."The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases".Molecular Endocrinology.15 (8):1318–28.doi:10.1210/mend.15.8.0682.PMID 11463856.
Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD (Jul 2002)."An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer".The EMBO Journal.21 (13):3434–42.doi:10.1093/emboj/cdf340.PMC 126089.PMID 12093744.
Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (Sep 2002)."Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor".The Journal of Biological Chemistry.277 (37):33571–9.doi:10.1074/jbc.M203531200.PMID 12093804.
Inui S, Lee YF, Chang E, Shyr CR, Chang C (Feb 2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes".Journal of Dermatological Science.31 (1):65–71.doi:10.1016/S0923-1811(02)00152-4.PMID 12615366.
Franco PJ, Li G, Wei LN (Aug 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase".Molecular and Cellular Endocrinology.206 (1–2):1–12.doi:10.1016/S0303-7207(03)00254-5.PMID 12943985.S2CID 19487189.
Mu X, Chang C (Oct 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3".The Prostate.57 (2):129–33.doi:10.1002/pros.10282.PMID 12949936.S2CID 24134119.
Li G, Franco PJ, Wei LN (Oct 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2".Biochemical and Biophysical Research Communications.310 (2):384–90.Bibcode:2003BBRC..310..384L.doi:10.1016/j.bbrc.2003.08.145.PMID 14521922.
Lin YL, Wang YH, Lee HJ (Nov 2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A".Biochemical and Biophysical Research Communications.350 (2):430–6.Bibcode:2006BBRC..350..430L.doi:10.1016/j.bbrc.2006.09.061.PMID 17010934.

This article on agene on humanchromosome 12 is astub. You can help Wikipedia byexpanding it.

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	BHLH 2 3 9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see alsotranscription factor/coregulator deficiencies

Retrieved from "https://en.wikipedia.org/w/index.php?title=Testicular_receptor_2&oldid=1321960001"

Categories:

Hidden categories:

[8]ページ先頭

Movatterモバイル変換

Testicular receptor 2

Interactions

See also

References

Further reading