Terbogrel

Names
IUPAC name (5E)-6-{3-[tert-Butyl(cyano)carbamimidamido]phenyl}-6-pyridin-3-ylhex-5-enoic acid
Other names (5E)-6-[m-(3-tert-Butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)-5-hexenoic acid
Identifiers
CAS Number	149979-74-8 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL281398 Y
ChemSpider	4952549 Y
KEGG	D06077 Y
PubChemCID	6449876
UNII	5Z4KWQ5OGN Y
InChI InChI=1S/C23H27N5O2/c1-23(2,3)28-22(26-16-24)27-19-10-6-8-17(14-19)20(11-4-5-12-21(29)30)18-9-7-13-25-15-18/h6-11,13-15H,4-5,12H2,1-3H3,(H,29,30)(H2,26,27,28)/b20-11+ Y Key: XUTLOCQNGLJNSA-RGVLZGJSSA-N Y InChI=1S/C23H27N5O2/c1-23(2,3)28-22(26-16-24)27-19-10-6-8-17(14-19)20(11-4-5-12-21(29)30)18-9-7-13-25-15-18/h6-11,13-15H,4-5,12H2,1-3H3,(H,29,30)(H2,26,27,28)/b20-11+
SMILES N#CN\C(=N/C(C)(C)C)Nc2cccc(C(=C/CCCC(=O)O)\c1cccnc1)c2
Properties
Chemical formula	C23H27N5O2
Molar mass	405.502 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Terbogrel (INN^[1]) is an experimental drug that has been studied for its potential to prevent the vasoconstricting and platelet-aggregating action ofthromboxanes. Terbogrel is an orally availablethromboxane A₂ receptor antagonist and athromboxane A synthase inhibitor.^[2][3] The drug wasdeveloped byBoehringer Ingelheim.

Aphase 2 clinical trial of terbogrel was discontinued due to its induction of leg pain.^[4]

• Ramatroban

• Antiplatelet drugs
• 3-Pyridyl compounds
• Guanidines
• Nitriles
• Tert-butyl compounds

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