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Teneligliptin

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Chemical compound

Pharmaceutical compound

Teneligliptin
Clinical data

Trade names	Tenelia
ATC code	A10BH08 (WHO)
Legal status
Legal status	Approved in Japan
Identifiers
IUPAC name {(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl}(1,3-thiazolidin-3-yl)methanone
CAS Number	760937-92-6
PubChemCID	11949652
ChemSpider	10123963
UNII	28ZHI4CF9C
CompTox Dashboard(EPA)	DTXSID30997419
Chemical and physical data
Formula	C₂₂H₃₀N₆OS
Molar mass	426.58 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=NN(C(=C1)N2CCN(CC2)[C@H]3C[C@H](NC3)C(=O)N4CCSC4)C5=CC=CC=C5
InChI InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1 Key:WGRQANOPCQRCME-PMACEKPBSA-N

Teneligliptin (INN; trade nameTenelia) is a pharmaceutical drug for the treatment oftype 2 diabetes mellitus. It belongs to the class of anti-diabetic drugs known asdipeptidyl peptidase-4 inhibitors or "gliptins".^[1]

It was created byMitsubishi Tanabe Pharma and launched in September 2012 by both Mitsubishi Tanabe Pharma andDaiichi Sankyo inJapan.^[2]

It is approved for use in Japan, Argentina, Korea and India.^[3]

Teneligliptin has unique J-shaped or anchor locked domain structure because of which it has a potent inhibition of DPP 4 enzyme.

Teneligliptin significantly controls glycemic parameters with safety. No dose adjustment is required in renally impaired patients.^[4]

^Kishimoto M (2013)."Teneligliptin: a DPP-4 inhibitor for the treatment of type 2 diabetes".Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.6:187–195.doi:10.2147/DMSO.S35682.PMC 3650886.PMID 23671395.
^"TENELIA® 20mg tablets, a Treatment for Type 2 Diabetes Mellitus Approval of Partial Change in Indication to Lift Restrictions in Combination Therapy".Media & Investors. Daiichi Sankyo. 20 December 2013. Archived fromthe original on 24 November 2015.
^Bronson J, Black A, Dhar TG, Ellsworth BA, Merritt JR (2013). "Teneligliptin (Antidiabetic), Chapter: To Market, To Market - 2012".Annual Reports in Medicinal Chemistry. Vol. 48. pp. 523–524.doi:10.1016/b978-0-12-417150-3.00028-4.ISBN 978-0-12-417150-3.
^Nabeno M, Akahoshi F, Kishida H, Miyaguchi I, Tanaka Y, Ishii S, Kadowaki T (May 2013). "A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site".Biochemical and Biophysical Research Communications.434 (2):191–196.Bibcode:2013BBRC..434..191N.doi:10.1016/j.bbrc.2013.03.010.PMID 23501107.

Fast-acting	Insulin aspart Insulin glulisine Insulin lispro
Short-acting	Regular insulin^#
Long-acting	Insulin detemir^# Insulin glargine^# (+lixisenatide) NPH insulin Lente insulin^‡ Ultralente insulin^‡
Ultra-long-acting	Insulin degludec^# (+insulin aspart,+liraglutide) Insulin icodec^† (+semaglutide)
Inhalable	Exubera^‡ Afrezza
Oral	Insulin tregopil^†

Non-insulins

Biguanides	Buformin^‡ Metformin^# Phenformin^‡
TZDs ("-glitazones") andPPAR agonists	Ciglitazone^§ Darglitazone^§ Englitazone^§ Lobeglitazone Netoglitazone^§ Pioglitazone Rivoglitazone^† Rosiglitazone Troglitazone^‡
Dual PPAR agonists	Aleglitazar^† Muraglitazar^§ Saroglitazar Tesaglitazar^§
Amylin analogues andDACRAs	Cagrilintide^§ Pramlintide

Sulfonylureas	1st generation:Acetohexamide Carbutamide Chlorpropamide Glycyclamide Metahexamide Tolazamide Tolbutamide 2nd generation:Glibenclamide (glyburide) Glibornuride Glicaramide Gliclazide^# Glimepiride Glipizide Gliquidone Glisoxepide Glyclopyramide
Meglitinides ("-glinides")	Mitiglinide Nateglinide Repaglinide

GLP1 poly-agonist peptides	Mazdutide (GLP-1/GCGR) Retatrutide^§ (GLP-1/GIP/GCGR) Tirzepatide (GLP-1/GIP)

Other

Aldose reductase inhibitors	Epalrestat Fidarestat^§ Ranirestat^† Tolrestat^‡ Zenarestat^§
Alpha-glucosidase inhibitors	Acarbose Miglitol Voglibose
SGLT2 inhibitors ("-gliflozins")	Canagliflozin Dapagliflozin Empagliflozin^# Ertugliflozin Ipragliflozin Luseogliflozin Remogliflozin^§ Sergliflozin^§ Sotagliflozin Tofogliflozin^† Velagliflozin
Other	Benfluorex^‡ Bromocriptine Imeglimin

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