| Monoclonal antibody | |
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| Type | Fab' fragment |
| Source | Mouse |
| Target | NCA-90 (granulocyte cell antigen) |
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Technetium (99mTc) sulesomab (trade nameLeukoScan) is a radio-pharmaceutical composed of anti-humanmousemonoclonal antibody[1] that targets the granulocyte associated NCA-90 cell antigen and a conjugatedtechnetium-99mradionuclide. After intravenous administration, Leukoscan enables sensitive and specific whole body measurement of granulocyte infiltration and activation bygamma camera imaging of99mTc-antibody bound cells.[2] Total clearance of LeukoScan from blood samples after administration and imaging has been reported at 48 hour time points indicating limited retention of the agent in circulation[3]
It is approved in European markets for the imaging ofinfections andinflammations in patients with suspectedosteomyelitis[4][5] but has not secured FDA approval for use in American markets.[6] In addition to approved uses, LeukoScan is currently being investigated for other diagnostic purposes like the detection ofsoft tissue infections, malignant external otitis and prosthetic joint infection.[7][8][9] However, the future clinical and investigational use of this agent may be limited as sale of the agent by the parent companyImmunomedics was discontinued in 2018.[10]
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