| tau-protein kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| EC no. | 2.7.11.26 | ||||||||
| CAS no. | 111694-09-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, atau-protein kinase (EC2.7.11.26) is anenzyme thatcatalyzes thechemical reaction
Thus, the twosubstrates of this enzyme areATP andtau protein, whereas its twoproducts areADP andO-phospho-tau-protein.
This enzyme belongs to the family oftransferases, specifically, those transferring a phosphate group to the sidechainoxygen atom ofserine orthreonine residues inproteins (protein-serine/threonine kinases). This enzyme participates in 14metabolic pathways:erbb signaling pathway,cell cycle,wnt signaling pathway,hedgehog signaling pathway,axon guidance,focal adhesion,b cell receptor signaling pathway,insulin signaling pathway,melanogenesis,alzheimer's disease,colorectal cancer,endometrial cancer,prostate cancer, andbasal cell carcinoma.
Thesystematic name of this enzyme class isATP:[tau-protein] O-phosphotransferase. Other names in common use includeATP:tau-protein O-hosphotransferase,brain protein kinase PK40erk,cdk5/p20,CDK5/p23,glycogen synthase kinase-3beta,GSK,protein tau kinase,STK31,tau kinase,[tau-protein] kinase,tau-protein kinase I,tau-protein kinase II,tau-tubulin kinase,TPK,TPK I,TPK II, andTTK.
As of late 2007, 3structures have been solved for this class of enzymes, withPDB accession codes2JDO,2JDR, and2UW9.
Human genes encoding proteins with Tau-protein kinase activity include:
