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| Other names | CP-24,441 |
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| Formula | C17H19N |
| Molar mass | 237.346 g·mol−1 |
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Tametraline (CP-24,441) is the parent of a series of chemical compounds investigated atPfizer that eventually led to the development ofsertraline.[1]
Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the sense that sertraline is theS,S-isomer whereas tametraline is the 1R,4S-stereoisomer.[citation needed]
1R-Methylamino-4S-phenyl-tetralin is a potent inhibitor of norepinephrine uptake in rat brain synaptosomes,[2] reversesreserpine induced hypothermia in mice, and blocks uptake of3H-Norepinephrine into rat heart.[3]
Tametraline is anorepinephrine–dopamine reuptake inhibitor.[4]
Indatraline is an indanamine homolog of tetralin-based tametraline, although in the case of indatraline the product is pm-dichlorinated.[citation needed]
