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Isn't tricine used to buffer solutions near neutral? If so, shouldn't it have a pKa near neutral? Current article only lists a very acidic pKa.ike989818:02, 21 November 2006 (UTC)[reply]

I've linked to a Good paper from Biochemistry in 1966. Technically, the article is right --- pKa1 is 2.3, but that's not the relevant pKa. That would be pKa2, which is 8.15 at 20c. I've changed accordingly and referenced. --18.103.24.17400:21, 15 August 2007 (UTC)[reply]

The chemical structure is impossible -- at no pH would the COO be protonated while the NH is deprotonated. Valid protonation states are either positive (NH2+, COOH), negative (NH, COO-), or zwiterionic (NH2+, COO-).Nfitzkee (talk)20:10, 28 November 2011 (UTC)[reply]

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