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Nifedipine and other calcium-channel blockers may interfere with the normal development ofsperm, potentially reducing thefertility of men who take it. It has been studied by at least one researcher as a potential reversiblemale contraceptive,[1] however, it is not being actively pursued as a contraceptive by any major pharmaceutical companies, possibly because of perceptions that publicizing its contraceptive effects would negatively impact sales as a blood-pressure medication, or because an expired patent and the availability of inexpensive generics makes research into new uses an unappealing financial prospect.[2]
At least one case of possible Nifedipine-induced infertility has been reported in the literature.[3].
Couples who are having difficulty conceiving should consult their doctor if the man is taking nifedipine.
The apparent contraceptive mechanism is an inhibition of the normalmannose lectin coating of the spermatozoa's outer membrane; this coating is necessary for correct binding with the egg. This may be caused when a greater-than-normal amount ofcholesterol is integrated into the membrane, stiffening the membrane and preventing normal outward migration of mannose from the interior.[1][2]
This is completely disproportionate to the rest of the article. One researcher pushing it and one case report on infertility make this too obscure for a general encyclopedia.JFW | T@lk22:54, 10 October 2006 (UTC)[reply]
Well, i came here looked specifically for this information... and despite a passing familiarity with mediawiki, i am not a wikipedian. To me, at least, this is a highly relevant section.66.173.237.26 (talk)03:26, 17 July 2011 (UTC)[reply]
References
^Goodwin, LO, NB Leeds, I Hurley, FS Mandel, RG Pergolissi and S Benoff (1997) “Isolation and characterization of the primary structure of testis-specific L-type calcium channel: implications for contraception.” Molecular Human Reproduction 3(3): 255-68.
^Benoff, S (1998) “Voltage dependent calcium channels in mammalian spermatozoa.” Frontiers in Bioscience 3: D1220-40.
This medication is deadly if taken in overdose. It should be kept out of the reach of children and anyone suspested of being depressed or suicidal.—Precedingunsigned comment added by108.3.64.13 (talk)16:13, 10 January 2010 (UTC)[reply]
Could someone mention Procardia XL dosage form release mechanism. Specifically that it is a plastic shell with a small opening that lets the drug out slowly. This is important since the nifedipine is released later and over a different kinetic time period. Also the shell can form a pseudobezoar within the patient. --74.179.121.14 (talk)16:15, 10 April 2011 (UTC)Procardia XL is an osmotic push-pull system. See Wikipedia "Osmotic controlled-release oral delivery system" or abbreviated OROS for an explanation. Because the shell of the system cannot be digested and is emptying within about 24h, it can in rare cases be collected in the stomach. The stomach has an sphincter muscle that is controlling the food and liquid transport to the small intestine. Larger bodies like the empty OROS shell may not pass this sphincter. This empty shell is called a bezoar.dieter.e.becker@gmail.com[reply]
Is this drug a cyp3a4 inhibitor? I know it is a substrate, but data on whether or not is inhibits said enzyme is contradictory at best. I know it could THEROTICALLY produce inhibition via competing with other drugs for the limited enzyme, but does this translate to having any useful inhibtion activity, and if so would it be worth taking as a inhibitor???— Precedingunsigned comment added by24.98.250.155 (talk)23:18, 14 September 2011 (UTC)[reply]
It contains only primary sources, and the titles of the journal articles don't give the impression that they are primarily about the mechanism of nifedipine. I would recommendWP:MEDRS-compatible secondary sources in the first instance.JFW | T@lk22:11, 26 October 2014 (UTC)[reply]
Seriously? You base your judgement on the TITLES of research articles?
The TITLES of the journal articles? Seriously? ThisJfdwolff guy didn't even read the actual research. Anyone can write a book (your secondary resources) and write whatever they like in it. Now talk about peer reviewed scientific articles. Take the time to read these references, if reading will actually make you understand what is written in them. If you can actually understand something that is not the instructions manual of Wikipedia, which I do believe you can't.Herizora (talk)22:45, 26 October 2014 (UTC)[reply]
Jfdwolff I do understand your point. However it doesn't change the fact that you based your judgement on the titles of the research papers alone. Sorry, but I am afraid that's rather obtuse. Regards.Herizora (talk)10:24, 28 October 2014 (UTC)[reply]
Herizora I agree in principle that it is much better to review the entire article. However, I don't always have access to the full text and it is generally not difficult to distinguish on the basis of more limited information alone.
I see that most of the additions are based on your PhD work. I really do hope that I can convince you to stick around and contribute further within the constraints of our policies.JFW | T@lk11:51, 28 October 2014 (UTC)[reply]
Jfdwolff Thanks for your response. I would like to share the information for the general public. That's it. But I believe it's not possible with the current policy of Wikipedia.Herizora (talk)12:40, 28 October 2014 (UTC)[reply]
Jfdwolff Although I did not take the trouble of adding the reference, the suggestions that nifedipine and other calcium channel blockers can reduce aldosterone levels in human subjects has been published by several groups as far as 1998 (16 years). It is possible to google it up, but then the title of the research papers may not give you the right clue about the contents.Herizora (talk)13:14, 28 October 2014 (UTC)[reply]
Herizora I accept that I might have been able to find a suitable secondary source in the fulltext of the papers cited. Could I suggest that you identify the best source (perWP:MEDRS) and add it to the article?JFW | T@lk13:23, 28 October 2014 (UTC)[reply]
Jfdwolff I will try to find a suitable reference, or an acceptable collection of references including review articles, and then try to add the relevant information to the article. Please make sure to watch it.Herizora (talk)13:39, 28 October 2014 (UTC)[reply]
References
^Azizan EA, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Teo AE, Davenport AP, Dekkers T, Tops B, Küsters B, Ceral J, Yeo GS, Neogi SG, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ. (2013)."Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension".Nature Genetics.45 (9):1055–1060.doi:10.1038/ng.2716.PMID23913004.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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Sublingual administration of nifedipine promotes a hypotensive effect via peripheral vasodilation. It can cause an uncontrollable decrease in blood pressure, reflex tachycardia, and a steal phenomenon in certain vascular beds. There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, including cerebral ischemia/infarction, myocardial infarction, complete heart block, and death.
Sublingual nifedipine causes blood-pressure lowering through a peripheral vasodilation. It can cause an uncontrollable decrease in the blood pressure, reflex tachycardia, and a steal phenomenon in certain vascular beds. There have been multiple reports in the medical literature of serious adverse effects with sublingual nifedipine, which include cerebral ischaemia/infarction, myocardial infarction, complete heart block and death.
These passages are virtually identical. So, who copied who?
Moreover, this "steal phenomenon" requires further explanation.
Furthermore, there are sources suggesting that nifedipineis a suitable choice of drug for treating hypertensive emergencies: <https://www.bmj.com/content/286/6358/19>. According to this article, nifedipine typically improves cerebral blood flow.
