Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Tachykinin receptor 3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
TACR3
Identifiers
AliasesTACR3, HH11, NK-3R, NK3R, NKR, TAC3RL, Tachykinin receptor 3, TAC3R, NK3
External IDsOMIM:162332;MGI:892968;HomoloGene:824;GeneCards:TACR3;OMA:TACR3 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for TACR3
Genomic location for TACR3
Band4q24Start103,586,031bp[1]
End103,719,985bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for TACR3
Genomic location for TACR3
Band3|3 G3Start134,534,768bp[2]
End134,640,340bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • hypothalamus

  • C1 segment

  • prefrontal cortex

  • amygdala

  • urinary bladder

  • substantia nigra

  • ventricular zone

  • corpus callosum

  • Brodmann area 9

  • primary visual cortex
Top expressed in
  • iris

  • ventral tegmental area

  • substantia nigra

  • vestibular sensory epithelium

  • stria vascularis

  • lumbar subsegment of spinal cord

  • lateral hypothalamus

  • Gonadal ridge

  • cornea

  • adrenal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6870

21338

Ensembl

ENSG00000169836

ENSMUSG00000028172

UniProt

P29371

P47937

RefSeq (mRNA)

NM_001059

NM_021382

RefSeq (protein)

NP_001050

NP_067357

Location (UCSC)Chr 4: 103.59 – 103.72 MbChr 3: 134.53 – 134.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tachykinin receptor 3, also known asTACR3, is aprotein which in humans is encoded by theTACR3gene.[5][6]

Function

[edit]

This gene belongs to a family of genes that function asreceptors fortachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to asneurokinin B.[6]

Selective ligands

[edit]

A number of selective ligands are available for NK3. NK3 receptor antagonists are being investigated as treatments for various indications.[7]

Agonists

[edit]
  • Neurokinin B – endogenous peptide ligand, also interacts with other neurokinin receptors but has highest affinity for NK3
  • Senktide – 7-amino acid polypeptide, NK3 selective, CAS# 106128-89-6

Antagonists

[edit]
  • Elinzanetant (BAY-3427080 GSK-1144814, NT-814)
  • Fezolinetant (ESN-364)
  • Osanetant (SR-142,801)
  • Pavinetant (MLE-4901, AZD-4901, AZD-2624)
  • Talnetant (SB-223,412)
  • SB-222,200 – potent and selective antagonist, Ki = 4.4 nM, 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide, CAS# 174635-69-9
  • SB-218,795 – more selective than SB-222,200, Ki = 13 nM, (R)-[(2-Phenyl-4-quinolinylcarbonyl)amino]-methyl ester benzeneacetic acid, CAS# 174635-53-1

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000169836Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028172Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Huang RR, Cheung AH, Mazina KE, Strader CD, Fong TM (Apr 1992). "cDNA sequence and heterologous expression of the human neurokinin-3 receptor".Biochemical and Biophysical Research Communications.184 (2):966–72.doi:10.1016/0006-291X(92)90685-E.PMID 1374246.
  6. ^ab"Entrez Gene: TACR3 tachykinin receptor 3".
  7. ^Quartara L, Altamura M (Aug 2006). "Tachykinin receptors antagonists: from research to clinic".Current Drug Targets.7 (8):975–92.doi:10.2174/138945006778019381.PMID 16918326.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Adhesion
Orphan
Other
Taste, sweet
Other
Frizzled
Smoothened
NK1
NK2
NK3


Stub icon

Thistransmembrane receptor-related article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Tachykinin_receptor_3&oldid=1301336492"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp