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TSPAN13

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

TSPAN13

Identifiers

Aliases

TSPAN13, NET-6, NET6, TM4SF13, tetraspanin 13

External IDs

OMIM:613139;MGI:1913359;HomoloGene:8671;GeneCards:TSPAN13;OMA:TSPAN13 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7p21.1	Start	16,753,755bp^[1]
Band	7p21.1	End	16,784,536bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 A3	Start	36,064,556bp^[2]
Band	12\|12 A3	End	36,092,499bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

visceral pleura

jejunal mucosa

endothelial cell

mucosa of sigmoid colon

Brodmann area 23

lower lobe of lung

germinal epithelium

bronchial epithelial cell

middle temporal gyrus

Top expressed in

habenula

lacrimal gland

subiculum

utricle

transitional epithelium of urinary bladder

crypt of lieberkuhn of small intestine

salivary gland

parotid gland

olfactory tubercle

right lung

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium channel regulator activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane
Biological process	cell surface receptor signaling pathway regulation of calcium ion transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


27075


66109

Ensembl


ENSG00000106537


ENSMUSG00000020577

UniProt


O95857


Q9D8C2

RefSeq (mRNA)


NM_014399


NM_025359

RefSeq (protein)


NP_055214


NP_079635

Location (UCSC)

Chr 7: 16.75 – 16.78 Mb

Chr 12: 36.06 – 36.09 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tetraspanin-13 is aprotein that in humans is encoded by theTSPAN13gene.^[5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as thetetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000106537 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000020577 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: TSPAN13 tetraspanin 13".

Böhme E, Graf H, Schultz G (1978). "Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets".Advances in Cyclic Nucleotide Research.9:131–43.PMID 27075.
Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye".J. Cell Sci.114 (Pt 23):4143–51.doi:10.1242/jcs.114.23.4143.PMID 11739647.
Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6 (9):791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Serru V, Dessen P, Boucheix C, Rubinstein E (2000). "Sequence and expression of seven new tetraspans".Biochim. Biophys. Acta.1478 (1):159–63.doi:10.1016/S0167-4838(00)00022-4.PMID 10719184.
Hu RM, Han ZG, Song HD, et al. (2000)."Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning".Proc. Natl. Acad. Sci. U.S.A.97 (17):9543–8.Bibcode:2000PNAS...97.9543H.doi:10.1073/pnas.160270997.PMC 16901.PMID 10931946.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003)."Human Chromosome 7: DNA Sequence and Biology".Science.300 (5620):767–72.Bibcode:2003Sci...300..767S.doi:10.1126/science.1083423.PMC 2882961.PMID 12690205.
Clark HF, Gurney AL, Abaya E, et al. (2003)."The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment".Genome Res.13 (10):2265–70.doi:10.1101/gr.1293003.PMC 403697.PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Huang H, Groth J, Sossey-Alaoui K, et al. (2005)."Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors".Clin. Cancer Res.11 (12):4357–64.doi:10.1158/1078-0432.CCR-04-2107.PMID 15958618.
Otsuki T, Ota T, Nishikawa T, et al. (2007)."Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries".DNA Res.12 (2):117–26.doi:10.1093/dnares/12.2.117.PMID 16303743.
Moroz MA, Serganova I, Zanzonico P, et al. (2007)."Imaging hNET reporter gene expression with 124I-MIBG".J. Nucl. Med.48 (5):827–36.doi:10.2967/jnumed.106.037812.PMID 17475971.

v t e Protein: cellmembrane proteins (other thanCell surface receptor,enzymes, andcytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see alsoother cell membrane protein disorders

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