TRPM7
Identifiers
Aliases	TRPM7, ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, transient receptor potential cation channel subfamily M member 7
External IDs	OMIM:605692;MGI:1929996;HomoloGene:9774;GeneCards:TRPM7;OMA:TRPM7 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 50,552,473bp[1] End 50,686,797bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 126,633,485bp[2] End 126,718,150bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle Achilles tendon cardiac muscle tissue of right atrium epithelium of colon sural nerve cartilage tissue testicle gastric mucosa right lobe of liver buccal mucosa cell Top expressed in molar Rostral migratory stream tail of embryo Gonadal ridge parotid gland saccule epithelium of small intestine pineal gland atrium genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding myosin binding metal ion binding kinase activity protein serine/threonine kinase activity ion channel activity actin binding ATP binding calcium channel activity Cellular component integral component of membrane membrane ruffle plasma membrane Biological process cellular magnesium ion homeostasis calcium-dependent cell-matrix adhesion programmed cell death phosphorylation actomyosin structure organization cation transport ion transport protein tetramerization protein phosphorylation calcium ion transmembrane transport protein autophosphorylation necroptosis calcium ion transport transmembrane transport Sources:Amigo /QuickGO
Orthologs Species Human Mouse Entrez 54822 58800 Ensembl ENSG00000092439 ENSMUSG00000027365 UniProt Q96QT4 Q923J1 RefSeq (mRNA) NM_001301212 NM_017672 NM_001164325 NM_021450 RefSeq (protein) NP_001288141 NP_060142 NP_001157797 NP_067425 Location (UCSC) Chr 15: 50.55 – 50.69 Mb Chr 2: 126.63 – 126.72 Mb PubMed search [3] [4]
Wikidata
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Transient receptor potential cation channel, subfamily M, member 7, also known asTRPM7, is a humangene encoding a protein of the same name.

TRPs, mammalian homologs of theDrosophilatransient receptor potential (trp) protein, areion channels that are thought to mediate capacitative calcium entry into the cell. TRPM7 is a protein that is both an ion channel and akinase. As a channel, it conducts calcium and monovalent cations todepolarize cells and increase intracellular calcium. As a kinase, it is capable ofphosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellularATP and by the kinase mutants.^[5]

TRPM7 has been shown tointeract withPLCB1^[6] andPLCB2.^[6]

Patients with pathogenic variants in the TRPM7 gene suffer from hypomagnesemia, seizures and developmental delay.^[7][8]

Defects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells.^[9]

• TRPM

• TRPM7+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

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