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TRPM4

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

TRPM4

Identifiers

Aliases

TRPM4, PFHB1B, TRPM4B, LTrpC4, htransient receptor potential cation channel subfamily M member 4, EKVP6

External IDs

OMIM:606936;MGI:1915917;HomoloGene:23033;GeneCards:TRPM4;OMA:TRPM4 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	49,157,741bp^[1]
Band	19q13.33	End	49,211,836bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B3	Start	44,952,056bp^[2]
Band	7\|7 B3	End	44,983,204bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

rectum

apex of heart

minor salivary glands

right uterine tube

skin of leg

skin of abdomen

Descending thoracic aorta

gallbladder

left lobe of thyroid gland

Top expressed in

jejunum

duodenum

colon

ileum

vestibular membrane of cochlear duct

left colon

muscle of thigh

stomach

esophagus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding calcium channel activity calmodulin binding ion channel activity ATP binding sodium channel activity calcium activated cation channel activity calcium ion binding metal ion binding
Cellular component	integral component of membrane Golgi apparatus membrane plasma membrane nucleoplasm endoplasmic reticulum cytosol soma sodium channel complex spanning component of plasma membrane spanning component of membrane
Biological process	adaptive immune response vasoconstriction immune system process positive regulation of canonical Wnt signaling pathway regulation of membrane potential cation transport ion transport protein sumoylation dendritic cell chemotaxis regulation of T cell cytokine production cardiac conduction positive regulation of cell population proliferation calcium ion transport negative regulation of bone mineralization positive regulation of atrial cardiac muscle cell action potential positive regulation of heart rate transmembrane transport positive regulation of adipose tissue development positive regulation of cytosolic calcium ion concentration calcium ion transmembrane transport positive regulation of fat cell differentiation positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of osteoblast differentiation positive regulation of vasoconstriction positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization ion transmembrane transport calcium-mediated signaling membrane depolarization during AV node cell action potential membrane depolarization during Purkinje myocyte cell action potential membrane depolarization during bundle of His cell action potential regulation of heart rate by cardiac conduction sodium ion import across plasma membrane regulation of ventricular cardiac muscle cell action potential protein homotetramerization cellular response to ATP inorganic cation transmembrane transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


54795


68667

Ensembl


ENSG00000130529


ENSMUSG00000038260

UniProt


Q8TD43


Q7TN37

RefSeq (mRNA)

NM_001195227 NM_017636 NM_001321281 NM_001321282 NM_001321283
NM_001321285


NM_175130

RefSeq (protein)

NP_001182156 NP_001308210 NP_001308211 NP_001308212 NP_001308214
NP_060106


NP_780339

Location (UCSC)

Chr 19: 49.16 – 49.21 Mb

Chr 7: 44.95 – 44.98 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known asmelastatin-4, is aprotein that in humans is encoded by the TRPM4gene.^[5]^[6]

TRPM4 Channel Blocker

[edit]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000130529 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000038260 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Xu XZ, Moebius F, Gill DL, Montell C (September 2001)."Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform".Proc. Natl. Acad. Sci. U.S.A.98 (19):10692–7.Bibcode:2001PNAS...9810692X.doi:10.1073/pnas.191360198.PMC 58528.PMID 11535825.
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels".Pharmacol. Rev.57 (4):427–50.doi:10.1124/pr.57.4.6.PMID 16382100.S2CID 17936350.

External links

[edit]

TRPM4+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Membrane transport protein:ion channels (TC 1A)

Ca²⁺:Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺:Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺:Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻:Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺:Proton channel	HVCN1
M⁺:CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺:TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+solutes):Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm:Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see alsodisorders

TRP channel modulators

TRPA

Activators

4-Hydroxynonenal
4-Oxo-2-nonenal
5,6-EET
12S-HpETE
15-Deoxy-Δ^12,14-prostaglandin J2
α-Sanshool (ginger,Sichuan andmelegueta peppers)
Acrolein
Allicin (garlic)
Allyl isothiocyanate (mustard,radish,horseradish,wasabi)
AM404
ASP-7663
Bradykinin
Cannabichromene (cannabis)
Cannabidiol (cannabis)
Cannabigerol (cannabis)
Cinnamaldehyde (cinnamon)
CR gas (dibenzoxazepine; DBO)
CS gas (2-chlorobenzal malononitrile)
Cuminaldehyde (cumin)
Curcumin (turmeric)
Dehydroligustilide (celery)
Diallyl disulfide
Dicentrine (Lindera spp.)
Farnesyl thiosalicylic acid
Formalin
Gingerols (ginger)
Hepoxilin A3
Hepoxilin B3
Hydrogen peroxide
Icilin
Isothiocyanate
JT-010
Ligustilide (celery,Angelica acutiloba)
Linalool (Sichuan pepper,thyme)
Methylglyoxal
Methyl salicylate (wintergreen)
N-Methylmaleimide
Nicotine (tobacco)
Oleocanthal (olive oil)
Paclitaxel (Pacific yew)
PF-4840154
Phenacyl chloride
Polygodial (Dorrigo pepper)
Shogaols (ginger,Sichuan andmelegueta peppers)
Tear gases
Tetrahydrocannabinol (cannabis)
Tetrahydrocannabiorcol
Thiopropanal S-oxide (onion)
Umbellulone (Umbellularia californica)
WIN 55,212-2

Blockers

TRPC

Activators	Adhyperforin (St John's wort) Diacyl glycerol GSK1702934A Hyperforin (St John's wort) Substance P
Blockers	DCDPC DHEA-S Flufenamic acid GSK417651A GSK2293017A Meclofenamic acid N-(p-Amylcinnamoyl)anthranilic acid Niflumic acid Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid

TRPM

Activators	ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10 Eucalyptol (eucalyptus) Frescolat MGA Frescolat ML Geraniol Hydroxycitronellal Icilin Linalool Menthol (mint) PMD 38 Pregnenolone sulfate Rutamarin (Ruta graveolens) Steviol glycosides (e.g.,stevioside) (Stevia rebaudiana) Sweettastants (e.g.,glucose,fructose,sucrose; indirectly) Thio-BCTC WS-12
Blockers	AMG-333 Capsazepine Clotrimazole DCDPC Elismetrep Flufenamic acid Meclofenamic acid Mefenamic acid N-(p-Amylcinnamoyl)anthranilic acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078 Ruthenium red Rutamarin (Ruta graveolens) Tolfenamic acid TPPO TRPM4-IN-5