TRPC1 is anion channel located on the plasma membrane of numerous human and animal cell types.[7]It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to thephospholipase C system. In HEK293 cells the unitary current-voltage relationship ofendogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV.[8] The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5.[9][10] The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.[10]
TRPC1 was the first mammalianTransient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to theTRP channel inDrosophila. Together with TRPC3 they became the founding members of theTRPCion channel family.[5][6]
^Skopin A, Shalygin A, Vigont V, Zimina O, Glushankova L, Mozhayeva GN, Kaznacheyeva E (Feb 2013). "TRPC1 protein forms only one type of native store-operated channels in HEK293 cells".Biochimie.95 (2):347–53.doi:10.1016/j.biochi.2012.10.004.PMID23079337.
^abCooper, Donald; Fowler, Melissa; Varnell, Andrew; Dietrich, A.; Birnbaumer, L.; Cooper, Donald (2012). "Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine".Nature Precedings.doi:10.1038/npre.2012.7153 (inactive 1 November 2024).{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
Rychkov G, Barritt GJ (2007). "TRPC1 Ca2+-Permeable Channels in Animal Cells".TRPC1 Ca(2+)-permeable channels in animal cells. Handbook of Experimental Pharmacology. Vol. 179. pp. 23–52.doi:10.1007/978-3-540-34891-7_2.ISBN978-3-540-34889-4.PMID17217049.
Ambudkar IS (Feb 2007). "TRPC1: a core component of store-operated calcium channels".Biochemical Society Transactions.35 (Pt 1):96–100.doi:10.1042/BST0350096.PMID17233611.
