Protein-coding gene in the species Homo sapiens
Two pore segment channel 2 (TPC2 ) is aprotein which in humans is encoded by theTPCN2 gene .[ 5] ion channel , however, in contrast to othercalcium andsodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).[ 6]
TPC2 is homologous to TPC1, the best characterized member of the TPC family. The structure of a TPC1ortholog fromArabidopsis thaliana [ 7] [ 8] X-ray crystallography and contained the fold of avoltage-gated ion channel andEF hands .
Filoviral infections [ edit ] Genetic knockout and pharmacological inhibition experiments demonstrate that thetwo-pore channels ,TPC1 andTPC2 , are required for infection by FilovirusesEbola andMarburg in mice.[ 9]
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