Two pore segment channel 1 (TPC1) is a humanprotein encoded by theTPCN1gene.[5] The protein encoded by this gene is anion channel. In contrast to othercalcium andsodium channels which have four homologous domains, each containing six transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).[6][7][8]
Genetic knockout and pharmacological inhibition experiments demonstrate that thetwo-pore channels,TPC1 andTPC2, are required for infection by FilovirusesEbola andMarburg in mice.[11]
^Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels".Biochemical and Biophysical Research Communications.270 (2):370–6.doi:10.1006/bbrc.2000.2435.PMID10753632.
^Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels".Pharmacological Reviews.57 (4):451–4.doi:10.1124/pr.57.4.7.PMID16382101.S2CID35096827.
Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels".Biochemical and Biophysical Research Communications.270 (2):370–6.doi:10.1006/bbrc.2000.2435.PMID10753632.
Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels".Pharmacological Reviews.57 (4):451–4.doi:10.1124/pr.57.4.7.PMID16382101.S2CID35096827.
