Transmembrane activator and CAML interactor (TACI), also known astumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is aprotein that in humans is encoded by theTNFRSF13Bgene.
TNFRSF13B is a transmembrane protein of theTNF receptor superfamily found predominantly on the surface ofB cells, which are an important part of the immune system.[5] TACI recognizes three ligands:APRIL,BAFF andCAML.
TACI mutations are associated with immunodeficiency in humans, as a significant proportion ofcommon variable immunodeficiency (CVID) patients have TACI mutations.[citation needed] People with this condition produce abnormally low amounts ofantibodies, which are needed for protection against infections.
In humans, the gene encoding this protein is located within theSmith–Magenis syndrome region on chromosome 17.[5]
TACI is currently being targeted for autoimmunity and B cell malignancies viaatacicept, a recombinant fusion protein that binds the TACI ligands BAFF and APRIL.[8]
^Yan M, Marsters SA, Grewal IS, Wang H, Ashkenazi A, Dixit VM (July 2000). "Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity".Nature Immunology.1 (1):37–41.doi:10.1038/76889.PMID10881172.S2CID22957179.
^von Bülow GU, Bram RJ (October 1997). "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily".Science.278 (5335):138–41.doi:10.1126/science.278.5335.138.PMID9311921.
Treml LS, Crowley JE, Cancro MP (October 2006). "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells".Seminars in Immunology.18 (5):297–304.doi:10.1016/j.smim.2006.07.001.PMID16919470.
Mackay F, Leung H (October 2006). "The role of the BAFF/APRIL system on T cell function".Seminars in Immunology.18 (5):284–9.doi:10.1016/j.smim.2006.04.005.PMID16931039.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
von Bülow GU, Bram RJ (October 1997). "NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily".Science.278 (5335):138–41.doi:10.1126/science.278.5335.138.PMID9311921.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A, Grossman A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W, Clegg CH (April 2000). "TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease".Nature.404 (6781):995–9.Bibcode:2000Natur.404..995G.doi:10.1038/35010115.PMID10801128.S2CID4323357.
von Bülow GU, Russell H, Copeland NG, Gilbert DJ, Jenkins NA, Bram RJ (August 2000). "Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse".Mammalian Genome.11 (8):628–32.doi:10.1007/s003350010125.PMID10920230.S2CID30311754.
Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M, McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ, Sarosi I, Hsu H, Senaldi G, Theill LE (September 2000). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity".Nature Immunology.1 (3):252–6.doi:10.1038/79802.PMID10973284.S2CID6799584.
Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS (August 2005). "TACI is mutant in common variable immunodeficiency and IgA deficiency".Nature Genetics.37 (8):829–34.doi:10.1038/ng1601.PMID16007086.S2CID20026177.
