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Decoy receptor 2

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(Redirected fromTNFRSF10D)

Protein-coding gene in the species Homo sapiens

TNFRSF10D

Identifiers

Aliases

TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, tumor necrosis factor receptor superfamily member 10d, TNF receptor superfamily member 10d

External IDs

OMIM:603614;HomoloGene:136778;GeneCards:TNFRSF10D;OMA:TNFRSF10D - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8p21.3	Start	23,135,588bp^[1]
Band	8p21.3	End	23,164,027bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cartilage tissue

pancreatic epithelial cell

stromal cell of endometrium

pancreatic ductal cell

islet of Langerhans

mucosa of ileum

right lobe of liver

endothelial cell

gastric mucosa

monocyte

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity TRAIL binding
Cellular component	integral component of membrane integral component of plasma membrane membrane plasma membrane cell surface
Biological process	multicellular organism development response to lipopolysaccharide inflammatory response negative regulation of apoptotic process regulation of cell population proliferation immune response signal transduction apoptotic process tumor necrosis factor-mediated signaling pathway regulation of apoptotic process leukocyte migration apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cell surface receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


8793


n/a

Ensembl


ENSG00000173530


n/a

UniProt


Q9UBN6


n/a

RefSeq (mRNA)


NM_003840


n/a

RefSeq (protein)


NP_003831


n/a

Location (UCSC)

Chr 8: 23.14 – 23.16 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Decoy receptor 2 (DCR2), also known asTRAIL receptor 4 (TRAILR4) andtumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a humancell surface receptor of theTNF-receptor superfamily.^[3]^[4]^[5]

Function

[edit]

The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor contains anextracellular TRAIL-binding domain, a transmembrane domain, and a truncatedcytoplasmic death domain.

Thisreceptor does not induceapoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000173530 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998)."A novel receptor for Apo2L/TRAIL contains a truncated death domain".Curr Biol.7 (12):1003–6.Bibcode:1997CBio....7.1003M.doi:10.1016/S0960-9822(06)00422-2.PMID 9382840.S2CID 21645158.
^Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998)."TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling"(PDF).FEBS Lett.424 (1–2):41–5.Bibcode:1998FEBSL.424...41P.doi:10.1016/S0014-5793(98)00135-5.PMID 9537512.S2CID 2964615.
^^a ^b"Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

Kimberley FC, Screaton GR (2005)."Following a TRAIL: update on a ligand and its five receptors".Cell Res.14 (5):359–72.doi:10.1038/sj.cr.7290236.PMID 15538968.
Degli-Esposti MA, Dougall WC, Smolak PJ, et al. (1998)."The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain".Immunity.7 (6):813–20.doi:10.1016/S1074-7613(00)80399-4.PMID 9430226.
Phillips TA, Ni J, Pan G, et al. (1999)."TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege".J. Immunol.162 (10):6053–9.doi:10.4049/jimmunol.162.10.6053.PMID 10229846.
Zhang XD, Franco AV, Nguyen T, et al. (2000)."Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells".J. Immunol.164 (8):3961–70.doi:10.4049/jimmunol.164.8.3961.PMID 10754286.
Daigle I, Simon HU (2001)."Alternative functions for TRAIL receptors in eosinophils and neutrophils".Swiss Medical Weekly.131 (17–18):231–7.doi:10.4414/smw.2001.09707.PMID 11420819.
Dörr J, Bechmann I, Waiczies S, et al. (2002)."Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain".J. Neurosci.22 (4): RC209.doi:10.1523/JNEUROSCI.22-04-j0001.2002.PMC 6757573.PMID 11844843.
Sun SY, Yue P, Chen X, et al. (2002). "The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells".Cancer Res.62 (8):2430–6.PMID 11956107.
Matysiak M, Jurewicz A, Jaskolski D, Selmaj K (2002)."TRAIL induces death of human oligodendrocytes isolated from adult brain".Brain.125 (Pt 11):2469–80.doi:10.1093/brain/awf254.PMID 12390973.
Robertson NM, Zangrilli JG, Steplewski A, et al. (2003)."Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival".J. Immunol.169 (10):5986–96.doi:10.4049/jimmunol.169.10.5986.PMID 12421985.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Ou D, Metzger DL, Wang X, et al. (2003)."TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction".Diabetologia.45 (12):1678–88.doi:10.1007/s00125-002-0926-2.PMID 12488957.
Hasel C, Dürr S, Rau B, et al. (2003)."In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas".Lab. Invest.83 (6):825–36.doi:10.1097/01.lab.0000073126.56932.46.PMID 12808117.
Kotelkin A, Prikhod'ko EA, Cohen JI, et al. (2003)."Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand".J. Virol.77 (17):9156–72.doi:10.1128/JVI.77.17.9156-9172.2003.PMC 187410.PMID 12915532.
Clark HF, Gurney AL, Abaya E, et al. (2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment".Genome Res.13 (10):2265–70.doi:10.1101/gr.1293003.PMC 403697.PMID 12975309.
Shivapurkar N, Toyooka S, Toyooka KO, et al. (2004)."Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types".Int. J. Cancer.109 (5):786–92.doi:10.1002/ijc.20041.PMID 14999791.S2CID 10876221.
Zhang Z, Henzel WJ (2005)."Signal peptide prediction based on analysis of experimentally verified cleavage sites".Protein Sci.13 (10):2819–24.doi:10.1110/ps.04682504.PMC 2286551.PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1 /CCRL1 CCR2 CCRL2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCR10
CXC	IL-8 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7
Other	CX3C CX3CR1 XC XCR1 CCBP2 CMKLR1

TNF receptor

1-10	TNFR1(TNFRSF1A) TNFR2(TNFRSF1B) LTBR(TNFRSF3) CD134(TNFRSF4) CD40(TNFRSF5) Fas receptor(TNFRSF6) DcR3(TNFRSF6B) CD27(TNFRSF7) CD30(TNFRSF8) CD137(TNFRSF9)
11-20	DR4(TNFRSF10A) DR5(TNFRSF10B) DcR1(TNFRSF10C) DcR2(TNFRSF10D) RANK(TNFRSF11A) Osteoprotegerin(TNFRSF11B) TweakR(TNFRSF12A) TACI(TNFRSF13B) BAFFR(TNFRSF13C) HVEM(TNFRSF14) NGFR(TNFRSF16) BCMA(TNFRSF17) GITR(TNFRSF18) TAJ/TROY(TNFRSF19)
21-27	DR6(TNFRSF21) DR3(TNFRSF25) EDA2R(TNFRSF27)

JAK-STAT

Type I

γ-chain	Interleukin receptors IL2R /IL2RA/IL2RB /IL15R IL4R /IL13R /IL13RA1 /IL13RA2 IL7R /IL7RA IL9R IL21R
β-chain	Interleukin receptors IL3R /IL3RA IL5R /IL5RA GM-CSF
gp130	Interleukin receptors IL6RA 11/IL11RA 27/IL27RA OSMR LIFR CNTFR
IL12RB1	Interleukin receptors IL12R/IL12RB1/IL12RB2 IL23R
Other	otherCSF receptors EPO G-CSF Thrombopoietin hormone receptor:GH prolactin

Type II

Interleukin receptors
- IL10R /IL10RA /IL10RB /IL22R /IL22RA1 /IL22RA2
- IL20R /IL20RA /IL20RB
- IL28R
Interferon receptors
- -α/β /IFNAR1/IFNAR2
- -γ/IFNGR1 /IFNGR2

Ig superfamily

IL1
- IL1R1
- IL1R2
IL18R /IL18R1

IL 17 family

IL17

Enzyme-linked receptor

Cytokine receptor modulators

Chemokine

Seehere instead.

CSF

Erythropoietin	Agonists:ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin delta Epoetin epsilon Epoetin gamma Epoetin kappa Epoetin omega Epoetin theta Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)
G-CSF (CSF3)	Agonists:Filgrastim Granulocyte colony-stimulating factor Lenograstim Leridistim Lipegfilgrastim Nartograstim Pegfilgrastim Pegnartograstim
GM-CSF (CSF2)	Agonists:Ecogramostim Granulocyte macrophage colony-stimulating factor Milodistim Molgramostim Regramostim Sargramostim Antibodies:Mavrilimumab Namilumab Otilimab
M-CSF (CSF1)	Agonists:Cilmostim Interleukin-34 Lanimostim Macrophage colony-stimulating factor Mirimostim Kinase inhibitors:Agerafenib
SCF (c-Kit)	Seehere instead.
Thrombopoietin	Agonists:Eltrombopag Pegacaristim Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

Interferon

IFNAR (α/β, I)	Agonists:Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1,IFNA2,IFNA4,IFNA5,IFNA6,IFNA7,IFNA8,IFNA10,IFNA13,IFNA14,IFNA16,IFNA17,IFNA21) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1,IFNB3) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b Antibodies:Anifrolumab Faralimomab MEDI-545 Rontalizumab Sifalimumab Decoy receptors:Bifarcept
IFNGR (γ, II)	Agonists:Interferon gamma (IFN-γ) Interferon gamma 1b Antibodies:Emapalumab Fontolizumab
IFNLR (λ, III)	See IL-28R (IFNLR)here instead.

Interleukin

Seehere instead.

TGFβ

Seehere instead.

TNF

Seehere instead.

Others

JAK
(inhibitors)

JAK1	Abrocitinib Baricitinib Deuruxolitinib Filgotinib Momelotinib Oclacitinib Peficitinib Ruxolitinib Tofacitinib (tasocitinib) Upadacitinib
JAK2	Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Deuruxolitinib Lestaurtinib NSC-7908 NSC-33994 Pacritinib Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib)
JAK3	Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P 154 ZM-39923 ZM-449829
TYK2	Deucravacitinib

Others

Additional cytokine receptor modulators:Emfilermin
Lestaurtinib
Midostaurin
Quizartinib
Sorafenib
Sunitinib

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References

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