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TL-1238

From Wikipedia, the free encyclopedia
Chemical compound
TL-1238
Names
Preferred IUPAC name
3-[(Dimethylcarbamoyl)oxy]-N,N-diethyl-N-methylanilinium iodide
Other names
Substance 3393
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C14H23N2O2.HI/c1-6-16(5,7-2)12-9-8-10-13(11-12)18-14(17)15(3)4;/h8-11H,6-7H2,1-5H3;1H/q+1;/p-1
    Key: HBVVWBFVSLUJNP-UHFFFAOYSA-M
  • CC[N+](C)(CC)c1cccc(c1)OC(=O)N(C)C.[I-]
Properties
C14H23IN2O2
Molar mass378.254 g·mol−1
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Extremely toxic
Lethal dose or concentration (LD, LC):
175 μg/kg (subcutaneous, mice)[1]
89 μg/kg (intravenous, mice)[1]
60 μg/kg (intravenous, mice)[2]
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

TL-1238 (Substance 3393) is an extremely potentcarbamateacetylcholinesterase inhibitor. It has been shown to be more potent than the parent compoundneostigmine.[2][3]

See also

[edit]

References

[edit]
  1. ^abChemical Warfare Agents, and Related Chemical Problems. Parts I-II. 1958.
  2. ^abBülbring, E; Chou, TC (March 1947)."The relative activity of prostigmine homologues and other substances as antagonists to tubocurarine".British Journal of Pharmacology and Chemotherapy.2 (1):8–22.doi:10.1111/j.1476-5381.1947.tb00316.x.PMC 1509759.PMID 19108106.
  3. ^BLASCHKO, H; BULBRING, E; CHOU, TC (March 1949)."Tubocurarine antagonism and inhibition of cholinesterases".British Journal of Pharmacology and Chemotherapy.4 (1):29–32.doi:10.1111/j.1476-5381.1949.tb00512.x.PMC 1509899.PMID 18113150.
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
BChETooltip Butyrylcholinesterase
Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
Enhancers
Blood agents
Blister agents
Arsenicals
Sulfur mustards
Nitrogen mustards
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GV agents
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choking agents
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Incapacitating
agents
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agents
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