Metalloproteinase inhibitor 4 is anenzyme that in humans is encoded by theTIMP4gene.[5][6][7]
This gene belongs to thetissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.[7]
^Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS (Sep 1998). "Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively".Genomics.51 (1):148–151.doi:10.1006/geno.1998.5362.PMID9693046.
Pohar N, Godenschwege TA, Buchner E (1999). "Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human".Genomics.57 (2):293–296.doi:10.1006/geno.1999.5776.PMID10198170.
Hernandez-Barrantes S, Shimura Y, Soloway PD, et al. (2001). "Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP".Biochem. Biophys. Res. Commun.281 (1):126–130.doi:10.1006/bbrc.2001.4323.PMID11178970.
Huang W, Li WQ, Dehnade F, Zafarullah M (2002). "Tissue inhibitor of metalloproteinases-4 (TIMP-4) gene expression is increased in human osteoarthritic femoral head cartilage".J. Cell. Biochem.85 (2):295–303.doi:10.1002/jcb.10138.PMID11948685.S2CID43053515.
Troeberg L, Tanaka M, Wait R, et al. (2003). "E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A)".Biochemistry.41 (50):15025–15035.doi:10.1021/bi026454l.PMID12475252.
Zhao YG, Xiao AZ, Park HI, et al. (2004). "Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion".Cancer Res.64 (2):590–598.doi:10.1158/0008-5472.CAN-03-1932.PMID14744773.S2CID15342778.
Lizarraga F, Espinosa M, Maldonado V, Melendez-Zajgla J (2005). "Tissue inhibitor of metalloproteinases-4 is expressed in cervical cancer patients".Anticancer Res.25 (1B):623–7.PMID15816637.
Koskivirta I, Rahkonen O, Mäyränpää M, et al. (2007). "Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology".Histochem. Cell Biol.126 (3):335–342.doi:10.1007/s00418-006-0163-8.PMID16521002.S2CID10581957.
